Golden Globes head Meher Tatna announced: “For generations, Oprah has celebrated strong female characters on and off screen, and has been a role model for women and young girls for decades.”
Oprah’s honor was announced by actor Morgan Freeman – who won the same prize in 2012.
The TV star will receive her award at January’s Golden Globes awards.
They are voted for by the Hollywood Foreign Press Association (HPFA).
The Oprah Winfrey Show was one of the most-watched programs in US history.
Meher Tatna described Oprah as “one of the most influential women of our time”.
The prize is presented annually at the Golden Globes ceremony, recognizing “a talented individual who has made an incredible impact on the world of entertainment”.
Meher Tatna described Oprah as a “global media leader, philanthropist, producer and actress”, adding: “She has created an unparalleled connection with people around the world, making her one of the most respected and admired figures today.”
Previous Cecil B. DeMille award winners include last year’s recipient, Meryl Streep, along with Audrey Hepburn, Barbra Streisand, Denzel Washington, George Clooney, Harrison Ford, Sidney Poitier and Martin Scorsese.
Along with her famous chat show, Oprah has also enjoyed a career as an actress, including an Oscar-nominated role in Steven Spielberg’s The Color Purple, in 1986.
She also starred in The Butler and Selma, which she produced.
Oprah Winfrey is also well-known for her charity work – this year marks the 10th anniversary of The Oprah Winfrey Leadership Academy for Girls in South Africa.
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