Relief operations are under way and engineers are working to restore power, but many areas remain stranded.
The islands of the Florida Keys and western parts of Florida bore the brunt of the category-four hurricane.
Irma hit Florida on September 10 and weakened to a tropical storm before becoming a tropical depression on September 12.
The storm was downgraded as it moved north towards Atlanta, with maximum sustained winds of 35mph later recorded, the National Hurricane Center (NHC) said in a statement.
The NHC statement said that while heavy rain was expected to continue across south-eastern states, all storm surge and tropical storm warnings had been discontinued.
Media reports link at least four deaths to the storm in Florida. Last week it killed at least 37 people in Caribbean islands.
Meanwhile, White House Homeland Security Adviser Tom Bossert has announced that it will be some time before residents in the Florida Keys are able to return to their homes.
“I would expect that the Keys are not fit for re-entry for regular citizenry for weeks,” he said.
Speaking as he went on an aerial tour of the Keys, Florida Governor Rick Scott said: “Power lines are down throughout the state. We’ve got roads that are impassable, so everybody’s got to be patient as we work through this.”
The Keys are cut off from the mainland, as the 42 bridges that link them are being assessed for damage. According to reports, 10,000 people decided to ride out the storm.
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