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The actors, who met in 2007 while filming the romantic comedy Take Me Home Tonight, said attempts to save their relationship had failed.
Chris Pratt wrote in a post on Facebook on August 6: “We tried hard for a long time, and we’re really disappointed.”
Anna Faris, 40, and Chris Pratt, 38, got married in 2009. They have a son named Jack.
Their statement added: “Our son has two parents who love him very much and for his sake we want to keep this situation as private as possible moving forward.”
It also added that the two had “cherished” their time together and “continue to have the deepest respect for one another”.
Chris Pratt, who played Andy Dwyer in the comedy series Parks and Recreation, has become one of Hollywood’s most sought-after leading men thanks to roles in Jurassic World and Marvel’s Guardians of the Galaxy.
In April, the actor paid a lengthy tribute to Anna Faris after receiving a star on the Hollywood Walk of Fame.
“Without you, none of this would mean anything,” he said.
Anna Faris had earlier praised Chris Pratt at the ceremony, introducing him to the stage with an emotional speech.
“I know that if our circumstances were different, and we weren’t as fortunate to be standing here and leading our Hollywood life, we would be happy in the woods together,” she said.
Anna Faris found fame in 2000 with Scary Movie, the spoof horror movie series in which she played Cindy Campbell in the first four installments.
She later co-starred alongside Sacha Baron Cohen in the controversial 2012 movie The Dictator.
Anna Faris went on to play the role of Christy Plunkett, a single mother who has battled with alcoholism and drug abuse in Chuck Lorre’s sitcom Mom.
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