The 35-year-old world No 2 had earlier posted a picture of herself on Snapchat posing in a mirror with the message: “20 weeks”, before deleting the post.
Serena Williams, who won an Open-era record 23rd Grand Slam in Australia in January, will miss the rest of the season.
This includes three Grand Slams – the French Open, Wimbledon and US Open.
Serena Williams, who will return to world No 1 next week, would be eligible to retain her ranking under the WTA special ranking rule if she is ready to play her first tournament within 12 months of giving birth.
US Open Tennis responded to Serena Williams’ message by saying: “Serena Williams will have a new pride and joy to hug and call her own soon! Congratulations on the exciting baby announcement!”
Serena Williams, who is engaged to the co-founder of community news and chat site Reddit, Alexis Ohanian, is top of the all-time list of major winners since Grand Slams accepted professional players in 1968. She is second only to Australian Margaret Court on the list of women’s all-time Grand Slam singles titles leaders.
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