The babies are due in June, according to host Julie Chen.
Another source close to the couple, quoted by People, said they were “very happy”. The Clooneys’ representatives have not yet commented.
George and Mal Clooney married in Venice in 2014 with a star-studded list of guests who included Matt Damon and Bill Murray.
Rumors that they might be expecting began to circulate last month when Amal Clooney, 39, was spotted wearing a loose-fitting dress.
George Clooney, 55, has starred in numerous Hollywood films and has won two Academy Awards.
Amal Clooney, a prominent human rights lawyer, has represented a number of high profile figures, including former Ukrainian PM Yulia Tymoshenko and Australian WikiLeaks founder Julian Assange.
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ivf for sure.