The standalone clip, entitled 3am, has been made public via YouTube.
Donald Trump is seen with a copy of a book called Great Speeches by A. Hitler in the video.
When Homer Simpson signals that he might vote for Donald Trump, Marge says: “If that’s your vote, I question whether I can ever be with you again.”
He replies: “And that’s how I became a Democrat.”
Donald Trump and Hillary Clinton are set to face each other in the presidential election, which takes place on November 8.
Marge and Homer Simpson’ discussion comes about when Marge says that she “can’t make love until I’ve decided who to vote for”.
The narrator then poses the question: “It’s 3am and the phone is ringing in the White House – who do you want to answer that call?”
The question is a reference to Hillary Clinton’s political campaign of 2008, which ran an ad featuring a ringing phone at 3am, asking Americans who they wanted leading their country during a time of crisis.
Both Hillary Clinton and Donald Trump are then seen responding to such a phone call.
Donald Trump responds by saying: “Not now, I’m on Twitter.”
The Republican then orders an aide to: “Put my name on the Lincoln memorial, disband NATO… and make me some scrambled eggs on gold plates.”
Former President Bill Clinton is seen initially answering the phone with: “The situation room? I’ll be right there.”
Bill Clinton’s face then falls as he hands the phone to Hillary, saying: “Oh, it’s for you.”
Hillary Clinton replies: “Yes, from now on, it’s always for me.”
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