Pilot Bertrand Piccard will attempt to reach Seville in Spain after about 90-hour flight from New York.
It is the first ever attempt to cross the Atlantic in a purely solar-powered aircraft.
Bertrand Piccard takes short naps while the plane is in flight.
The Atlantic crossing will be “the longest distance we have had to fly this year,” the Solar Impulse team said.
The flight was supposed to begin on June 19 but was delayed by bad weather.
Bertrand Piccard, a psychiatrist, is sharing the 22,000 mile round-the-world journey with Swiss entrepreneur Andre Borschberg.
The Solar Impulse, which has the wingspan of a Boeing 747, is covered in 17,000 photovoltaic cells to capture the sun’s rays.
The aircraft landed at New York’s John F. Kennedy International Airport on June 11 after a five-hour flight from Lehigh Valley in Pennsylvania.
The record attempt began on March 9, 2015, in Abu Dhabi, and has taken the aircraft across Asia and the Pacific to the US.
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