Egyptian state TV says local security forces repelled the attack and one assailant has been killed.
Reports vary as to the nationalities of the victims, and whether they were shot or stabbed.
Egypt is battling Islamist militants based in the nearby Sinai Peninsula, including an Islamic State affiliate.
An attack on a bus at a hotel near the Giza pyramids on January 7 was claimed by ISIS, which said it was targeting “a tourist bus carrying Jews”.
Egyptian officials said no-one was hurt in the attack, near Cairo. Arab Israeli tourists were staying at the hotel, reports said.
Hurghada is on the Red Sea coast, across the water from the resort of Sharm el-Sheikh, from where the Russian passenger plane which crashed in the Sinai Peninsula took off on October 31.
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