The pontiff has begun his trip to the US, where he is expected to greet millions of American Catholics and address thorny issues like climate change and income inequality.
Pope Francis will visit Washington DC, New York and Philadelphia.
Before he departed Cuba, the pontiff called on its people to live a “revolution of tenderness”.
In the final Mass of his four-day visit to the island, with President Raul Castro attending, he urged thousands of Cubans to serve one another and not an ideology.
On the trip from Cuba to the US, the Pope held a news conference and answered those who said his criticisms of capitalism went too far.
“I’ve never said anything that is not in the social doctrine of the church,” the Pope told reporters.
“Maybe I have given the impression of (being) a bit lefty, but that would be a mistaken interpretation.”
When he landed at Andrews Air Force Base, Pope Francis was greeted by Barack Obama and his family along with Vice-President Joe Biden and his wife.
The crowd, which included a military honor guard, schoolchildren, politicians, and Roman Catholic clergymen, chanted: “Welcome to the USA! Hello! Hey!”
After a brief chat with President Barack Obama, the pope rode away in a small charcoal-gray Fiat as part of a motorcade bound for the Vatican diplomatic mission in Washington.
Authorities have launched one of the biggest security operations in US history to ensure the pope’s safety.
The pontiff, who has sought to bring Catholics back to the church with a more inclusive message, is very popular in the US and is expected to draw massive crowds in all three cities.
A large portion of central Philadelphia will be practically closed off during his visit and federal employees in Washington have been urged to work remotely while Pope Francis is in the capital.
The event could attract up to a million and a half people.
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