American Alan Purwin and South American Carlos Berl died when their small plane crashed in the Colombian Andes.
Another American, Jimmy Lee Garland, survived Friday’s accident.
“Our hearts and prayers go out to the crew members and their families at this difficult time,” said Universal Pictures, distributor of Doug Liman’s film Mena.
Tom Cruise will appear in the movie as an American drug runner recruited by the DEA (Drug Enforcement Agency) in the 1980s to help it capture cocaine kingpin Pablo Escobar.
Jimmy Lee Garland had been working as a flying double for Tom Cruise, whose spokesperson has yet to comment on the crash.
In a statement on its website, Alan Purwin’s company Helinet Technologies remembered him as “a great man, a world-renowned aviator and a brilliant entrepreneur”.
“There are no words that can express our heartache for we have lost one of the world’s greatest helicopter pilots,” wrote its CEO, Steve Gatena.
It is not known what caused the crash, though bad weather has been cited as a possible factor.
Tom Cruise previously worked with Doug Liman on his 2014 blockbuster Edge of Tomorrow and is set to work with him again on sci-fi movie Luna Park, according to reports.
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