At least 17 have also died in India.
The 7.3-magnitude earthquake has struck eastern Nepal, near Mount Everest, two weeks after more than 8,000 people died in a devastating quake.
It hit near the town of Namche Bazaar and sent thousands of panicked residents on to the streets of Nepal’s capital, Kathmandu.
The April 25 quake’s magnitude was 7.8.
The latest quake struck at 12:35 Nepali time and was centered about 47 miles east of Kathmandu, in a rural area close to the Chinese border.
The quake was felt in northern India, Tibet and Bangladesh. India’s home ministry said 16 people had been killed in the state of Bihar, and one more in Uttar Pradesh. Officials in China said one person was confirmed dead in Tibet.
Rescue helicopters have been sent to districts east of Kathmandu that are believed to be worst hit.
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