Fire Commissioner Daniel Nigro said that the blaze started shortly after midnight and that those killed were all between 5 and 15 years old.
A woman believed to be the children’s mother and a teenager escaped by jumping out of second-floor windows.
Both survivors are in a critical condition in hospital, suffering from burns and smoke inhalation.
Speaking at a press conference on March 21, Daniel Nigro said that the incident was the “largest tragedy by fire that this city has had in seven years”.
“It’s a tragedy for this family, it’s a tragedy for this community, it’s a tragedy for the city,” he added.
FDNY spokesman Jim Long said that more than 100 fire-fighters had worked to bring the blaze under control.
The fire was believed to have been started by a malfunctioning hot plate in the kitchen.
Daniel Nigro said that the family had become trapped on the second floor when the fire reached the stairs, cutting off their escape.
“There was no evidence of smoke detectors on either the first or the second floor that may have alerted this family to the fire,” he said.
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