Red Nose Day on NBC will raise money for charities in Africa, Asia, Latin America and the US.
Comic Relief in the UK has raised more than £1billion ($1.5 billion) since the charity was co-founded by filmmaker Richard Curtis 30 years ago.
Richard Curtis, an executive producer for the NBC special, said he hoped it would make a “massive difference” to millions of children around the world.
Since the first TV fundraiser in 1988, the biennial Red Nose Day in the UK has seen celebrities and normal people do something funny for money on TV, at home, school, and work.
Emma Watson, Daniel Craig and Orlando Bloom were among the stars appearing in the 2015 special, which aired last week, helping to raise £78 million ($117 million) by the end of the live show.
NBC has yet to announce who will appear on the show, but Mad Men star Jon Hamm starred in an advert that aired during the Super Bowl.
The 12 charities that will benefit from donations to the US show include the Boys & Girls Clubs of America, Children’s Health Fund and United Way.
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