The Democrat politicians plan to meet Cuban officials and civilian leaders to discuss practical measures required for the normalization of relations.
The thaw in relations was announced on December 17 by President Barack Obama and his Cuban counterpart, Raul Castro.
Earlier this week, Cuba completed the release of 53 political prisoners.
The measure was agreed as part of the agreement.
“We have all been to Cuba before, and we strongly support the president’s new direction for our policy towards Cuba,” said Senator Patrick Leahy.
New travel and trade rules between the US and Cuba came into effect on January 16, also as part of the historic deal.
Americans will be able to take home up alcohol and tobacco from Cuba up to the value of $100.
US credit and debit cards can be used there and there will be no more limits on how much money US citizens can spend in Cuba each day.
While ordinary tourism is still banned, the new regulations will allow US citizens to travel to Cuba for any of a dozen specific reasons without first obtaining a special license from the government.
Although the latest moves put a large dent in the US trade embargo against the island’s communist government, only Congress can lift it completely.
The first high-level talks between Cuba and the US will be held in Havana on January 21 and 22.
The US delegation will be led by Assistant Secretary of State Roberta Jacobson.
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