France declared an orange weather alert, its second-highest, as local authorities scrambled to put up motorists for the night.
One man died when his vehicle slid into a ravine in the Isere region.
The French government asked drivers to “exercise the utmost caution” and avoid travel if possible.
Three people died in other snow-related incidents across France earlier this week, according to Le Monde.
Snowy conditions in the French Alps are expected to persist on December 28, followed by freezing weather next week when Paris should see its first frosts in more than a year, French weather forecasters say.
Local gyms and community halls were opened up as shelters in the Savoy region on December 27.
Motorists seeking accommodation “stormed” the Chambery exhibition centre, according to a live page on the website of Le Dauphine Libere newspaper.
Strong winds caused damage elsewhere in France, shutting the port of Calais, where an anti-migrant fence was partially toppled.
Closer to Paris, the celebrated gardens of Versailles were closed to the public because of gales.
Heavy snow caused disruption to roads in Germany too, causing a 16-mile traffic jam on the A8 motorway near Stuttgart.
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