The Band Aid 30’s single shifted more than 312,000 copies last week, making it 2014’s fastest-selling single so far.
It is the fourth version of the track to be released, and featured artists include Bastille and Rita Ora. Each version has made it to No 1.
Organizer Bob Geldof said the UK version of the song is also number one in France and 61 other countries.
All proceeds from the song go towards the fight against Ebola in West Africa.
Bono, Ed Sheeran, One Direction, Emile Sande and Ellie Goulding are also among those who perform on the single.
The song outsold the rest of the top five combined, scoring the biggest one-week sales since Impossible by the X Factor’s James Arthur shifted 489,000 copies in 2012.
The original Band Aid 1984 sold a million copies in the first week alone and became fastest-selling single at the time in the UK, raising £8 million ($10 million) for famine relief.
Sales of Band Aid 30 are expected to rise once a physical CD version is released on December 8.
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