Nobel Prize in Physiology or Medicine 2014: John O’Keefe, May-Britt Moser and Edvard I. Moser share award

This year’s Nobel Prize for physiology or medicine has been awarded to three scientists who discovered the brain’s “GPS system”.

Prof. John O’Keefe as well as May-Britt Moser and Edvard I. Moser share the award.

They discovered how the brain knows where we are and is able to navigate from one place to another.

Their findings may help explain why Alzheimer’s disease patients cannot recognize their surroundings.

“The discoveries have solved a problem that has occupied philosophers and scientists for centuries,” the Nobel Assembly said.

Prof. John O’Keefe, from University College London, discovered the first part of the brain’s internal positioning system in 1971.

On hearing about winning the prize, he said: “I’m totally delighted and thrilled, I’m still in a state of shock, it’s the highest accolade you can get.”

His work showed that a set of nerve cells became activated whenever a rat was in one location in a room.

A different set of cells were active when the rat was in a different area.

Prof. John O’Keefe argued these “place cells” – located in the hippocampus – formed a map within the brain.

In 2005, husband and wife team, May-Britt and Edvard, discovered a different part of the brain which acts more like a nautical chart.

These “grid cells” are akin to lines of longitude and latitude, helping the brain to judge distance and navigate.

The work at the Norwegian University of Science and Technology in Trondheim.

The Nobel committee said the combination of grid and place cells “constitutes a comprehensive positioning system, an inner GPS, in the brain”.

They added: “[This system is] affected in several brain disorders, including dementia and Alzheimer’s disease.

“A better understanding of neural mechanisms underlying spatial memory is therefore important and the discoveries of place and grid cells have been a major leap forward to advance this endeavor.”

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