Organizers said the actor, director and producer would be given its Cecil B. DeMille award for “his outstanding contributions both in front of and behind the camera”.
George Clooney, 53, was being recognized “as much for his global humanitarian efforts as he is for his accomplishments in the entertainment industry,” the Hollywood Foreign Press Association (HFPA) said.
The Golden Globes awards ceremony take place on January 11, 2015.
Recent recipients of the DeMille award, named after the famed producer of The Ten Commandments, include Martin Scorsese, Steven Spielberg, Jodie Foster and late actor Robin Williams.
Woody Allen was honored at this year’s event, though the actor and director did not travel to Los Angeles to collect his accolade.
George Clooney is no stranger to the Golden Globes, having been previously honored by the HFPA for his performances in The Descendants, O Brother Where Art Thou and Syriana.
George Clooney is expected to tie the knot shortly with human rights lawyer Amal Alamuddin.
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