Witnesses near the crash site reported hearing a loud noise and seeing a large plume of smoke in the sky.
Officials lost contact with the Massachusetts Air National Guard F-15 shortly before the crash, police said.
No injuries on the ground have been reported and rescue workers have been dispatched to the area, police added.
Major Matthew Mutti, a spokesman for the Massachusetts Air National Guard, said the single-seat aircraft had been on a routine training exercise and had no munitions on board.
Augusta County Sheriff’s office said the plane went down at around 09:00 local time.
Jenny McNeal, a spokeswoman for the sheriff’s office, said the crash site was in a rural area near Deerfield town in George Washington and Jefferson National Forests.
The US Air Force currently has 249 F-15 jets in operation and they have been deployed to both Iraq and Afghanistan in recent years.
The type that crashed in Virginia was an F-15C, which costs $30 million.
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