Some communities would be placed under quarantine as well, President Ellen Johnson Sirleaf said.
Non-essential government workers will be sent home for 20 days and the army deployed to enforce the measures.
The number of people killed by the virus in West Africa has now reached 672, according to new UN figures.
Treatment facilities have reportedly been overwhelmed in the Liberian capital Monrovia.
Some wards have already filled up, forcing health workers to treat some patients at their homes.
President Ellen Johnson Sirleaf said that Friday, August 1, would be a non-working day in Liberia to allow for the disinfection of all public facilities.
“All non-essential staff – to be determined by the heads of ministries and agencies – are to be placed on 30 days’ compulsory leave” she added.
The US humanitarian organization Peace Corps said it was withdrawing 340 volunteers from Liberia, Sierra Leone and Guinea because of the spread of the virus.
Ebola kills up to 90% of those infected, but patients have a better chance of survival if they receive early treatment.
The virus spreads through contact with an infected person’s bodily fluids.
The Ebola outbreak – the world’s deadliest to date – was first reported in Guinea in February. It then spread to Liberia and Sierra Leone.
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