Max Steinberg, 24, and Nissim Sean Carmeli, 21, were fighting for the Israel Defense Forces (IDF).
They were among 13 Israeli soldiers killed on Sunday. More than 100 Palestinians were also killed on Sunday.
The UN Security Council has called for an immediate ceasefire in Gaza.
“We can confirm the deaths of US citizens Max Steinberg and Sean Carmeli in Gaza,” state department spokeswoman Jen Psaki said on Sunday, declining to provide further details.
Max Steinberg, who hailed from California, was reportedly a sharpshooter for the Golani Brigade, the Associated Press news agency reports.
“He was completely dedicated and committed to serving the country of Israel,” his father, Stuart Steinberg, told the AP.
“He was focused, he was clear in what the mission was, and he was dedicated to the work he needed to be doing.”
Sean Carmeli was a sergeant from Texas who moved to Israel four years before.
More than 500 Palestinians, mainly civilians, have been killed since the Israeli offensive began 13 days ago, Gaza’s health ministry says.
Meanwhile, Hamas launched fresh rocket attacks and used tunnels to infiltrate Israel near the town of Sderot. All 10 intruders were killed, Israel said.
Twenty Israelis – 18 of them soldiers – have died, Israel says, as it seeks to end rocket fire from Gaza.
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