The ANC won a commanding victory in the country’s general election on May 7.
More than 4,000 guests are expected at the ceremony in Pretoria, including Zimbabwean President Robert Mugabe.
Neither the US or UK are sending a representative but officials from Russia, China and India are attending.
President Jacob Zuma was officially elected for a second five-year term on Wednesday by the ANC-dominated parliament.
The expected formality of the re-election was disturbed only by lawmakers from the Economic Freedom Fighters (EFF), who turned up at parliament in red overalls and hardhats.
The EFF, led by former ANC member Julius Malema, said they dressed as maids and miners to show they intend to represent the interest of workers.
South African media say Saturday’s inauguration ceremony will be as much about celebrating Nelson Mandela and 20 years of democracy as about officially sealing Jacob Zuma’s re-election.
Jacob Zuma will take the oath of office shortly after prayers open the ceremony at 11:00 local time.
Several heads of state will be in attendance, including Robert Mugabe, Nigeria’s Goodluck Jonathan, and Ugandan President Yoweri Museveni.
The US is not sending a representative but a White House statement said President Barack Obama spoke to Jacob Zuma on Friday to congratulate him on his re-election.
The centrepiece of the event is a 90-minute cultural show, with performances from local musicians, dancers and a youth choir.
Proceedings will be broadcast at 45 public viewing sites across the country as well as being shown live on television and radio.
Around 20,000 people are also expected to descend on the Union Building in Pretoria, the site of the ceremony, to watch on large TV screens.
Jacob Zuma will get back to work immediately after the national celebrations and is expected to announce his cabinet on Sunday.
lc3JadRA8aMThe bald eagle has been officially declared the national bird of the United States, after…
Dozens of passengers have survived a crash involving a plane carrying 69 people in Kazakhstan,…
Millions of Americans are bracing for difficult weather conditions during the Christmas holiday, with storms…
The US House Ethics Committee has voted to release its report on former Republican Representative…
ABC News has agreed to pay $15 million to President-elect Donald Trump to settle a…
South Korea’s parliament has voted to impeach President Yoon Suk Yeol over his failed attempt…