The film, which is being released as Bad Neighbors in the US, sold $51 million of tickets over the weekend.
The Amazing Spider-Man 2 took $37 million, according to estimates.
Cameron Diaz comedy The Other Woman held onto third place with Heaven Is for Real and Captain America: The Winter Soldier completing the top five.
Neighbors sees Seth Rogen and Rose Byrne as new parents who find themselves engaged in a battle of wits when a rowdy fraternity house, led by a frequently shirtless Zac Efron, moves in next door.
The sequel to The Amazing Spider-Man, which sees Andrew Garfield reprise his role as the web-slinging superhero, has made more than $550 million in worldwide ticket sales so far.
Christian drama Heaven Is for Real has been the surprise hit of the year so far. Telling the story of a 4-year-old who says he experienced Heaven during emergency surgery, it has earned more than $75 million on an estimated budget of just $12 million.
US box office Top 5:
Source: Rentrak
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