Arsen Avakov announced on Facebook that a criminal case had been opened against Viktor Yanukovych and other officials over “mass murder of peaceful citizens”.
Ukraine’s parliament voted to remove Viktor Yanukovych on Saturday after months of protest sparked by his rejection of an EU deal.
A crackdown on the protests last week left dozens dead.
“An official case for the mass murder of peaceful citizens has been opened,” said Arsen Avakov.
“Yanukovych and other people responsible for this have been declared wanted.”
The statement said Viktor Yanukovych was last seen in Balaklava on the Crimean peninsula on Sunday, but that he had left by car for an unknown destination, accompanied by an aide.
Before leaving Balaklava Viktor Yanukovych gave his state-appointed security detail the choice to leave him, with many choosing to do so, the statement said.
It did not say which other figures were covered by the warrant.
Arsen Avakov – a key opposition figure – was appointed interim interior minister on Saturday, in a day of fast-paced events in parliament.
He replaced Vitaly Zakharchenko, who was sacked the day before after being blamed for the deaths of civilians in the crackdown on protesters.
The protests first began in late November when Viktor Yanukovych rejected a landmark association and trade deal with the EU in favor of closer ties with Russia.
Ukraine’s health ministry says 88 people, mostly anti-Yanukovych protesters but also police, are now known to have been killed in last week’s clashes.
Viktor Yanukovych insisted on Saturday that he was still Ukraine’s legitimate leader. But he had become increasingly isolated and parliament voted to impeach him and hold presidential elections in May.
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