A panel of experts mandated by the UN’s Human Rights Council said North Koreans had suffered “unspeakable atrocities”.
The panel heard evidence of torture, enslavement, sexual violence, severe political repression and other crimes.
It is expected to recommend an inquiry by an international court or tribunal.
Testimony to the panel has included an account of a woman forced to drown her own baby, children imprisoned from birth and starved, and families tortured for watching a foreign soap opera.
The full report is expected to contain hundreds of pages of further evidence of a nationwide policy of control through terror, says our correspondent.
The Associated Press quoted from a leaked version of the panel’s report, which accuses the regime of taking decisions aimed at maintaining its own rule “in full awareness that such decisions would exacerbate starvation and related deaths amongst much of the population”.
For years, North Korean defectors have detailed harrowing accounts of life under the brutally repressive Kim dynasty.
The regime keeps tens of thousands of political prisoners in camps, and divides the population up in terms of presumed loyalty to the regime.
Civilians live under a system of neighborhood surveillance where they are encouraged to denounce each other, according to defectors.
Although this information has been in the public domain for years, the panel’s inquiry is the highest-profile international attempt to investigate the claims.
North Korea refused to participate and has rejected any claims of rights violations and crimes against humanity.
Jared Genser, an international human rights lawyer who has campaigned to stop crimes against humanity in North Korea, said the findings were both ground-breaking and unremarkable.
“They’re ground-breaking in that it’s the first time that the United Nations as an institution has found that crimes against humanity are being committed against the people of North Korea,” he said.
“Of course, it puts a huge burden on the United Nations to then take the next set of steps.”
“But of course it’s also unremarkable in the sense that those of us who have worked on North Korea human rights for many, many years are aware of the sheer weight of evidence coming out of North Korea over decades now… And so the real question now is, what next?”
According to AP, which has seen an outline of the report’s findings, the document will conclude that the testimony and other information it received “merit a criminal investigation by a competent national or international organ of justice”.
However, China would be likely to block any attempt to refer the North to the International Criminal Court.
And an ad-hoc tribunal like those set up for Rwanda, Sierra Leone or Cambodia would appear unlikely without any co-operation from elements within the country.
The UN panel will formally present its findings in March, when the Human Rights Council will decide which recommendations to support.
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