The new kit will include figures of the main characters including Homer, Bart, Marge and Ned Flanders.
LEGO struck the deal with the show’s owners, Twentieth Century Fox.
Fox is scheduled to air an episode of The Simpsons featuring the cast in Lego form in May, in the US.
“We know our fans will love the challenge of building the Simpsons’ family home in great detail and the ability to collect quintessential characters in Lego minifigure form,” Jill Wilfert, from the LEGO Group said in a statement.
The Simpsons, a satirical parody of family life, has been running for 25 years making it the longest running scripted TV show in the US.
LEGO new set will go on sale in the US in February priced at $199.99. The company plans to launch a separate line of 16 Simpsons mini figures in May.
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