Speaking in the capital, Caracas, Henrique Capriles said not voting on December 8 could be “very costly”.
Henrique Capriles was speaking as thousands turned out for a day of protest.
On Wednesday, the National Assembly gave President Nicolas Maduro controversial new powers to rule by decree.
Nicolas Maduro says the powers will enable him to fight corruption and fix the economy.
The National Assembly’s measure allows Nicolas Maduro to govern without consulting parliament for 12 months.
Despite being a big oil producer, Venezuela is facing shortages of food and other essential goods, as well as power cuts and 54% inflation.
Nicolas Maduro has already forced retailers to slash prices by up to 60%, as part of his fight against what he calls “economic sabotage”.
The government has also imposed strict controls over the sale of foreign currency, to combat a growing black market in dollars.
The opposition accuses Nicolas Maduro of planning to use his new powers to suppress its activities.
Local elections will take place in two weeks.
“Everybody has to overcome their fears and vote. Voting doesn’t cost a thing, but not doing it can be very costly,” Henrique Capriles, who narrowly lost to Nicolas Maduro in April’s presidential election, told the crowd on Saturday.
Henrique Capriles said two of his aides were detained without explanation on Thursday night.
He accused Nicolas Maduro of being too cowardly to arrest him, relying instead on detaining people around him.
“Why don’t they come for me? Maduro, don’t be a coward, come on,” Henrique Capriles told supporters.
One of those arrested was man in charge of organizing Henrique Capriles’ travel agenda, Alejandro Silva.
The government confirmed two members of the opposition had been arrested, accused of planning to provoke disturbances during Saturday’s protests.
jmb1RBOjiQoThe US House Ethics Committee has voted to release its report on former Republican Representative…
ABC News has agreed to pay $15 million to President-elect Donald Trump to settle a…
South Korea’s parliament has voted to impeach President Yoon Suk Yeol over his failed attempt…
Israeli war planes have carried out more than 100 air strikes in Syria on December…
President-elect Donald Trump has threatened to impose 100% tariffs on the BRICS countries if they…
Syrian troops have withdrawn from the city of Aleppo following an offensive by rebels opposed…