Categories: Front PageHealth

Malaria vaccine shows promising results in early stage clinical trials

US researchers say a malaria vaccine has shown promising results in early stage clinical trials.

Researchers found the vaccine protected 12 out of 15 patients from the disease, when given in high doses.

The method is unusual because it involves injecting live but weakened malaria-causing parasites directly into patients to trigger immunity.

The research is published in the journal Science.

Lead author Dr. Robert Seder, from the Vaccine Research Center at the National Institutes of Health, in Maryland, said: “We were excited and thrilled by the result, but it is important that we repeat it, extend it and do it in larger numbers.”

It has been known for several decades that exposure to mosquitoes treated with radiation can protect against malaria.

The new vaccine involves injecting live but weakened malaria-causing parasites directly into patients to trigger immunity

However, studies have shown that it takes more than 1,000 bites from the insects over time to build up a high level of immunity, making it an impractical method of widespread protection.

Instead, a biotech company called Sanaria has taken lab-grown mosquitoes, irradiated them and then extracted the malaria-causing parasite (Plasmodium falciparum), all under sterile conditions.

These living but weakened parasites are then counted and placed in vials, where they can then be injected directly into a patient’s bloodstream. This vaccine candidate is called PfSPZ.

To carry out the Phase-1 clinical trial, the researchers looked at a group of 57 volunteers, none of whom had had malaria before.

Of these, 40 received different doses of the vaccine, while 17 did not. They were then all exposed to the malaria-carrying mosquitoes.

The researchers found that for the participants not given any vaccine, and those given low doses, almost all became infected with malaria.

However for the small group given the highest dosage, only three of the 15 patients became infected after exposure to malaria.

Dr. Robert Seder said: “Based on the history, we knew dose was important because you needed 1,000 mosquito bites to get protection – this validates that.

“It allows us in future studies to increase the dose and alter the schedule of the vaccine to further optimize it. The next critical questions will be whether the vaccine is durable over a long period of time and can the vaccine protect against other strains of malaria.”

He added that the fact that the vaccine had to be injected into the bloodstream rather than into or under the skin made delivery more difficult.

There are currently about 20 malaria vaccine candidates in clinical trials.

The most advanced is called RTS,S/AS01, which has been developed by the pharmaceutical company GlaxoSmithKline, and is in a Phase-3 clinical trial involving 15,000 children in Africa.

According to the latest figures from the World Health Organization, there were an estimated 219 million cases of malaria in 2010 and an estimated 660,000 deaths.

TCwBWrKSSyc
Kathryn R. Bown

Kathryn - Our health specialist likes to share with the readers the latest news from the field. Nobody understands better than her the relation between healthy mind and healthy body.

Recent Posts

Donald Trump and Elon Musk Celebrate Election Victory at UFC 309

Image source: Wikimedia Commons President-elect Donald Trump celebrated his election victory at the Ultimate Fighting…

5 days ago

White House 2024: Donald Trump Wins, Kamala Harris Calls Him to Concede Election

Millions of voters across the US chose to return Donald Trump to the White House…

2 weeks ago

Who Won? Donald Trump Declares Victory as He Addresses Jubilant Supporters in Florida

Donald Trump declares victory in the US election as he addresses jubilant supporters in Florida.…

2 weeks ago

Stocks Soaring as Donald Trump Closes in on US Victory

Stocks around the world are rising as Donald Trump appears to be on the cusp…

2 weeks ago

Who Won? Kamala Harris Cancels Election Night Party as Path to Victory Narrows

Donald Trump has won Pennsylvania, North Carolina and Georgia and taken a lead over Kamala…

2 weeks ago

Quincy Jones Dead at 91

Quincy Jones, the celebrated musician and producer who worked with Michael Jackson, Frank Sinatra, Ray…

2 weeks ago