Aaron Motsoaledi said 94,000 schoolgirls also fell pregnant in 2011, and 77,000 had abortions at state facilities, The Sowetan newspaper reports.
About 10% of South Africans are living with HIV, official statistics show.
Aaron Motsoaledi has been widely praised for his efforts to curb the disease.
South Africa has run the world’s largest anti-retroviral (ARV) programme since President Jacob Zuma appointed Aaron Motsoaledi as health minister in 2009.
The number of HIV-positive people receiving life-saving ARV drugs more than doubled from 678,500 to 1.5 million after he took office, according to official statistics.
The government of former President Thabo Mbeki, who questioned the link between HIV and AIDS, had argued it could not afford to roll out this treatment to all the South Africans who needed it.
Speaking at a public meeting in the town of Carolina in South Africa’s Mpumalanga province, Aaron Motsoaledi said the large number of young girls who were HIV-positive “destroyed my soul”.
“It is clear that it is not young boys who are sleeping with these girls. It is old men,” The Sowetan quotes him as saying.
“We must take a stand against sugar daddies because they are destroying our children.”
Aaron Motsoaledi said some pregnant girls – aged between 10 and 14 years of age – also tested positive for HIV.
“[About] 77 000 girls had abortions at public facilities. We can no longer live like that. We want to put an end to it,” he said.
More than 5 million people in South Africa are HIV-positive – about 10% of the total population.
Last year more than 260,000 people with AIDS died – almost half the figure of all those who died in South Africa.
Image source: Wikimedia Commons President-elect Donald Trump celebrated his election victory at the Ultimate Fighting…
Millions of voters across the US chose to return Donald Trump to the White House…
Donald Trump declares victory in the US election as he addresses jubilant supporters in Florida.…
Stocks around the world are rising as Donald Trump appears to be on the cusp…
Donald Trump has won Pennsylvania, North Carolina and Georgia and taken a lead over Kamala…
Quincy Jones, the celebrated musician and producer who worked with Michael Jackson, Frank Sinatra, Ray…