Information Minister Ernesto Villegas said Hugo Chavez’s condition continued to be very delicate.
Hugo Chavez, 58, returned to Venezuela last month after being treated for cancer in Cuba, but has not appeared in public since.
Many Venezuelans have been demanding full details about his health.
Ernesto Villegas read out the latest brief update on national television.
Speaking from the Caracas military hospital where Hugo Chavez is being treated, Ernesto Villegas said: “Today there is a worsening of respiratory function.”
He said Hugo Chavez was undergoing “intensive chemotherapy, as well as complementary treatments”.
“The commander-president remains clinging to Christ and to life, conscious of the difficulties that he is facing, and complying strictly with the programme designed by his medical team,” Ernesto Villegas said.
Hugo Chavez, who has been in office for 14 years, is believed to have cancer in his pelvic area, but his exact illness has never been disclosed.
The resident announced in June 2011 that he had cancer and has undergone four operations since then, as well as chemotherapy and radiation therapy.
Hugo Chavez was re-elected for another six-year term in October 2012, but the Supreme Court ruled that his swearing-in on January 10 could be delayed because of his illness.
At the weekend, hundreds of Venezuelan students and opposition members marched in Caracas demanding full details about Hugo Chavez’s health.
He is said to be taking decisions about the country from the hospital bed but there have been mixed messages from officials on his condition.
Vice President Nicolas Maduro said on Saturday that President Hugo Chavez was still having chemotherapy.
On Thursday, Nicolas Maduro had gone on TV to say Hugo Chavez was battling for his life.
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