MPs earlier passed the 2013 budget drawn up by his government with 309 votes in favor and 55 against.
An announcement on whether Mario Monti will take part in elections – expected in February – will probably be made at a news conference on Sunday.
Mario Monti was brought in to form a technocratic government last year.
However, the conservative People of Freedom party of his predecessor, Silvio Berlusconi, withdrew its support for his cabinet this month.
Silvio Berlusconi, a three-time prime minister already, is fighting his sixth election campaign.
The new political uncertainty in Italy, the third-biggest economy in the eurozone, has unsettled investors.
Mario Monti travelled to the presidential palace after a cabinet meeting late on Friday to hand in his resignation to President Giorgio Napolitano.
President Giorgio Napolitano accepted the resignation and called on Mario Monti to remain as head of an interim administration until the elections, which analysts say will most probably be held on February 24.
The date will be determined after President Giorgio Napolitano consults with political leaders on Saturday and dissolves the two chambers.
In his last speech before his resignation, Mario Monti said his 13 months in office had been “difficult but fascinating”.
“The work we did… has made the country more trustworthy… more competitive and attractive to foreign investors,” Mario Monti told foreign diplomats in Rome.
Opinion polls suggest the centre-left Democratic Party, under Pierluigi Bersani, will win the largest share of the vote in the election.
Since taking office with his non-party team of ministers, Mario Monti has been implementing economic austerity measures and argues that his spending cuts and tax hikes have staved off disaster.
The economist and former European commissioner cannot stand for election himself as he is already a senator for life but he could theoretically return as a minister, perhaps as unofficial leader of a centrist coalition.
“Those closest to him say he has not yet decided and do not rule out a surprise decision,” the Italian daily Corriere Della Sera said.
“Slowly, as the hours pass, the largest parties which supported Monti begin to see him as a potential adversary.”
On Thursday, Mario Monti, 69, defended the “bitter medicine” of budgetary discipline, in what appeared to be a response to attacks by Silvio Berlusconi on austerity policies.
Mario Monti told workers at the Fiat factory that it would be “irresponsible to waste all the sacrifices that Italians [had] made”.
On Friday, he joked that the impending end of his technocratic government was “not the fault of the Mayan prophecy”, referring to a prediction that the world would end on Friday.
SG4XKPex8jMQuincy Jones, the celebrated musician and producer who worked with Michael Jackson, Frank Sinatra, Ray…
Misleading allegations, rumours and outright lies about voting and fraud are flooding online spaces in…
At least 158 people have died in Spain's worst flooding disaster in generations. On October…
Google has been fined two undecillion (a two followed by 36 zeroes) roubles by a…
Embarking on a home remodel is an exciting journey, promising enhanced comfort, increased property value,…
The US presidential candidates continued to campaign across key swing states on October 20. Footage…