Opposition activists used social networks to mobilize the march, which they said was one of the biggest anti-government protests in a decade.
Those gathered said they were angry at rising inflation, high levels of crime and high-profile corruption cases.
President Cristina Fernandez de Kirchner was re-elected by a landslide to a second term in 2011.
Her approval ratings have since dropped and protests against some of her policies have mounted.
Official figures say inflation is at 12%, but analysts say it is probably much higher.
The International Monetary Fund warned Argentina in September that unless it produced reliable growth and inflation data by December, it could face sanctions.
Protesters also voiced their objections to restrictions introduced last year, and further sharpened this year, on the purchase of dollars, which have made it harder for Argentines worried about inflation to trade in their currency.
The government says the slowdown of the Argentine economy is the fault of the global financial crisis rather than its policies.
Supporters of President Cristina Fernandez de Kirchner say the protests are driven by people from the middle and upper class worried about losing their privileges.
They point to policies supporting the poor, such as cash payments to the unemployed, as the real achievements of her government.
oLFcz-uk-I8Image source: Wikimedia Commons President-elect Donald Trump celebrated his election victory at the Ultimate Fighting…
Millions of voters across the US chose to return Donald Trump to the White House…
Donald Trump declares victory in the US election as he addresses jubilant supporters in Florida.…
Stocks around the world are rising as Donald Trump appears to be on the cusp…
Donald Trump has won Pennsylvania, North Carolina and Georgia and taken a lead over Kamala…
Quincy Jones, the celebrated musician and producer who worked with Michael Jackson, Frank Sinatra, Ray…