Hillary Clinton will meet Prime Minister Benjamin Netanyahu, as well as President Shimon Peres and other officials.
She was in Egypt over the weekend, where she met new President Mohammed Mursi.
Hillary Clinton is expected to share her impressions of the new Egypt with Israeli officials.
She will tell officials in Jerusalem that Egypt’s President Mohammed Mursi reiterated in private what he has said in public – that Egypt will abide by all its international agreements.
Those agreements include a peace treaty with Israel.
Israel said to be anxious about the rise of Islamists in neighboring Egypt after the ousting of Hosni Mubarak, who was a long-time American ally.
On her trip to Cairo, Hillary Clinton met President Mohammed Mursi and, separately, the head of Egypt’s top military council, Field Marshal Mohamad Hussein Tantawi.
The president has been in conflict with the military council, which ruled the country after Mubarak was forced out, over parliament’s dissolution.
On Saturday, Hillary Clinton told Mohammed Mursi that the situation required “compromise and real politics” but also voiced support for a “full transition to civilian rule”.
The secretary of state also encouraged Mohammed Mursi to live up to promises to protect the rights of women and minorities, and to preserve the peace treaty with Israel.
In her talks with Field Marshal Mohamad Hussein Tantawi on Sunday Hillary Clinton discussed the transition of power to the newly elected president and stressed the need to protect the rights of all Egyptians, US officials said.
Speaking later at the newly re-opened US consulate in Alexandria, Hillary Clinton said: “I want to be clear that the United States is not in the business, in Egypt, of choosing winners and losers, even if we could, which of course we cannot.”
Hillary Clinton also held meetings with leading women, the Coptic Christian community and young entrepreneurs in Egypt.
She said: “Democracy is not just about reflecting the will of the majority. It is also about protecting the rights of the minority.”
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