Niamh Clarke-Willis joined LOCOG head Lord Sebastian Coe to hit a button which launched balloons into the sky above the venue for this summer’s Games.
Around 40,000 members of the public were at the Olympic Stadium in Stratford to witness the opening, which included a laser light show.
The “2,012 hours to go” event tested the park’s management and security.
Lord Sebastian Coe said: “It’s a fantastic feeling. The seven years have just flown by. Tonight is only the start of the story.
“We want thousands of young people to be inspired to take up sport. We hope that for a few of them it will be the start of their journey.
“I’m grateful to everyone who came here tonight to celebrate this moment in history.”
Spectators had to queue to enter the venue after airport-style security checks.
Simon Levy, who came to the Olympic Park for the first time on Saturday, said: “It’s not a problem, really. It’s much quicker than the airport and it’s good to be checked because now we know we’re safe.”
Police helicopters flew over the park and armed police patrolled the area.
Adrian Casy, a security guard at the Olympic Stadium, said Saturday’s events were among the main rehearsals for the games, particularly in moving and managing the crowds of spectators from the park and from one venue to another.
“Honestly, so far, so good, although we’re still trying hard to make it run smoother,” said Adrian Casy, adding that some spectators were wearing “insufficient clothing” to cope with the weather conditions.
TV presenters Vernon Kay and Gabby Logan hosted the event which saw entertainment from impressionist Jon Culshaw, actor Hugh Bonneville, singer and former Spice Girl Melanie C, rapper Chipmunk and comedian Jack Whitehall.
Some 140,000 people are expected at the Olympic site over six days.
The celebrations are part of the British Universities and Colleges Sport Outdoor Athletics Championships and the Visa London Disability Grand Prix which are test events for the venue.
London 2012 hopefuls Perri Shakes-Drayton and Holly Bleasdale are competing at the BUCS event which runs from 4-7 May.
Later in the week, the Olympic Stadium will also play host to the Sainsbury’s 2012 School Games, for 1,600 school-aged elite athletes.
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