Pancreatic cancer may be treatable with new drugs that turn-off its gene

British researchers at the Cancer Research UK say aggressive pancreatic tumors may be treatable with a new class of drugs.

Less than one in five people with this form of cancer are still alive a year after being diagnosed.

A study, published in the journal Nature, showed that a gene was being switched off in the cancerous cells.

The researchers said drugs were already being tested which had the potential to turn the gene back on, to stop the spread of the cancer.

Around 7,800 people in the UK are diagnosed with pancreatic cancer every year and it is the fifth most deadly cancer.

British researchers at the Cancer Research UK say aggressive pancreatic tumors may be treatable with a new class of drugs

Studies in mice showed that a gene called USP9x, which normally stops a cell from dividing uncontrollably, is switched off in some pancreatic cancer cells.

The gene is not mutated, but other proteins and chemicals become stuck to it and turn the gene off.

Studies then showed that UPS9x was being turned off in human pancreatic cancer.

Prof. David Tuveson, from the Cancer Research UK Cambridge Research Institute, said: “We suspected that the fault wasn’t in the genetic code at all, but in the chemical tags on the surface of the DNA that switch genes on and off, and by running more lab tests we were able to confirm this.

“Drugs which strip away these tags are already showing promise in lung cancer and this study suggests they could also be effective.”

Dr. David Adams, from the Wellcome Trust Sanger Institute, said: “This study strengthens our emerging understanding that we must also look into the biology of cells to identify all the genes that play a role in cancer.”

They argue that up to 15% of pancreatic cancers could be down the turning this one gene off.

Dr. Julie Sharp, Cancer Research UK’s senior science information manager, said: “These results raise the possibility that a class of promising new cancer drugs may be effective at treating some pancreatic cancers.”

 

Kathryn R. Bown

Kathryn - Our health specialist likes to share with the readers the latest news from the field. Nobody understands better than her the relation between healthy mind and healthy body.

Recent Posts

Quincy Jones Dead at 91

Quincy Jones, the celebrated musician and producer who worked with Michael Jackson, Frank Sinatra, Ray…

5 hours ago

White House 2024: Voter Fraud Claims Flood Social Media

Misleading allegations, rumours and outright lies about voting and fraud are flooding online spaces in…

2 days ago

Spain: At Least 158 Killed In The Country’s Worst Flooding Disaster

At least 158 people have died in Spain's worst flooding disaster in generations. On October…

4 days ago

Russia Fines Google $20,000,000,000,000,000,000,000,000,000,000,000, Surpassing Global GDP

Google has been fined two undecillion (a two followed by 36 zeroes) roubles by a…

4 days ago

Financing Your Home Remodel: 7 Tips for Success

Embarking on a home remodel is an exciting journey, promising enhanced comfort, increased property value,…

2 weeks ago

Donald Trump Serves Up McDonald’s Fries While Kamala Harris Celebrates 60th Birthday with Church Choir

The US presidential candidates continued to campaign across key swing states on October 20. Footage…

2 weeks ago