Halle Berry, 45, sat down in the audience at the start of the show after apparently arriving late to the ceremony due to the notorious traffic in the area.
She ended up being the butt of the joke as she was covered in gunge by a young attendee sitting behind her.
Halle Berry wasn’t the only striking star to be punished by the television network’s annual gag.
Supermodel Heidi Klum found herself being spurted by the slippery liquid as she presented at the 25th annual event with Chris Colfer.
After tricking Chris Colfer into taking to the microphone where the offending orange blip was situated, the gunk which he got covered in, hit her accidentally and ruined her beige frock.
In a section of the show where Taylor Lautner competed against host Will Smith in a push-up contest, the comedian arranged that the Twilight Saga hunk be sprayed the hardest and he could barely contain himself to stand up and run away as a result.
The awards were broadcast from the Galen Center at USC in Los Angeles where kids’ top choices in television, movies, music and sports were revealed through a flying blimp, silver robot and sword swallower.
Will Smith made a stunning aerial entrance by parachuting down from the official KCA blimp, a 246-foot orange airship situated above the arena.
He then kicked off the silver anniversary celebration with a performance of Can U Handle This.
Throughout the ceremony, Will Smith’s mission was to find the culprit known as Creepy Voice, who wanted to ruin the show.
Although it turned out to be The Voice mentor Cee Lo, the presenter got so worked up about the game that he jokingly kicked his children Willow and Jaden out of the venue, much to their older brother Trey and mother Jada’s disappointment.
However he hadn’t really turfed his famous offspring from the show, instead they were preparing backstage to present their friend Justin Bieber with a gong.
Will Smith trapped Justin Bieber into the biggest slime fest of the event and the stage ended up covered by the luminous stuff as did the pair.
While much of the audience were in the firing line too, Victoria Beckham sat in the third row with son Cruz on her knee and Brooklyn and Romeo next to X Factor USA judge L.A Reid.
Victoria Beckham was wearing a super short black dress which she kept trying to adjust for the family show.
Highlights of the show included a spectacular performance by Katy Perry who sang her new single Part of Me while prancing around with numerous dancers.
After collecting her gong for Favourite Voice in an Animated Movie, Katy Perry told the audience: “The only reason why I’m still here today – and remember this – is because I’ve never grown up!”
Additionally Taylor Swift was recognized for her charitable personality and the First Lady of The United States, Michelle Obama, praised her for helping causes such as more books in schools and libraries and trying to tackle the bullying issue in her songs.
The 22-year-old was blown away by the unexpected Big Help award and told Michelle Obama: “Thank you so much I have always wanted to meet you. I am freaking out.”
Favourite TV Show: Victorious
Favourite Reality Show: Wipeout
Favorite TV Actor: Jake Short (A.N.T. Farm)
Favourite TV Actress: Selena Gomez (Wizards of Waverly Place)
Funniest TV Sidekick: Jennette McCurdy (iCarly)
Favourite Cartoon: SpongeBob SquarePants
Favorite Male Athlete: Tim Tebow
Favorite Female Athlete: Danica Patrick
Favorite Movie: Alvin and the Chipmunks: Chipwrecked
Favorite Movie Actor: Adam Sandler (Jack & Jill)
Favorite Movie Actress: Kristen Stewart (The Twilight Saga: Breaking Dawn, Part 1)
Favorite Animated Movie: Puss in Boots
Favorite Voice from an Animated Movie: Katy Perry (The Smurfs)
Favorite Music Group: Big Time Rush
Favorite Male Singer: Justin Bieber
Favorite Female Singer: Selena Gomez
Favorite Song: “Party Rock Anthem” (by LMFAO)
Favorite Book: Diary of a Wimpy Kid series
Favorite Videogame: Just Dance 3
Favorite Buttkicker: Taylor Lautner
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