Genes switch on and off can influence serious heart conditions

A new Nature Genetics report says that scientists may be closer to understanding how genes can influence serious heart conditions.

The failure to turn off a specific gene at the right time in an embryo’s development could mean illness later in life.

Mice in which the gene was left active were born apparently healthy, but suffered heart muscle problems later.

A heart charity said it might one day be possible to fix the genetic switch.

The science of “epigenetics”, which places importance not just on the genes you carry, but also how well they are working, is a relatively new area.

The scientists from the Gladstone Institute in San Francisco focused on two genes, and their role in cardiomyopathy, a enlarging and weakening of the heart muscle which is a feature in life-threatening heart defects in children and adults

There is increasing evidence that suggests that while you carry the same set of genes for life, environmental factors, such as diet or even your mother’s health while you are in the womb, could affect their activity, and your chances of certain illnesses later in life.

The scientists from the Gladstone Institute in San Francisco focused on two genes, and their role in cardiomyopathy, a enlarging and weakening of the heart muscle which is a feature in life-threatening heart defects in children and adults.

One of the genes, called Six1, appears to play an important role in embryonic heart development, while the other, Ezh2, seems to have the job of switching off genes, including Six1, when they are no longer needed.

The scientists tested the precise relationship by stopping Ezh2 from working in the embryo and foetus at various points during pregnancy, thereby allowing Six1 to go on working for longer than usual.

They found that while the mice were born apparently normal and healthy, they then started to develop the signs of cardiomyopathy.

This suggested that although leaving Six1 switched on in humans might produce a seemingly healthy baby, it could be storing up heart problems for later in life.

Analysis of the results revealed that, in a healthy pregnancy, Six1 should only normally be switched on briefly during heart development.

Dr. Paul Delgado-Olguin, one of the team, said: “When Six1 remains active for too long in Ezh2-deficient mice, it boosts the activity of other genes that shouldn’t be activated in heart muscle cells – such as genes that make skeletal muscle.

“The enlargement and thickening of the mice’s hearts over time eventually led to heart failure.”

They are hopeful that further work will reveal more about the roots of congenital heart problems in early life.

Kathryn R. Bown

Kathryn - Our health specialist likes to share with the readers the latest news from the field. Nobody understands better than her the relation between healthy mind and healthy body.

Recent Posts

Quincy Jones Dead at 91

Quincy Jones, the celebrated musician and producer who worked with Michael Jackson, Frank Sinatra, Ray…

7 hours ago

White House 2024: Voter Fraud Claims Flood Social Media

Misleading allegations, rumours and outright lies about voting and fraud are flooding online spaces in…

2 days ago

Spain: At Least 158 Killed In The Country’s Worst Flooding Disaster

At least 158 people have died in Spain's worst flooding disaster in generations. On October…

4 days ago

Russia Fines Google $20,000,000,000,000,000,000,000,000,000,000,000, Surpassing Global GDP

Google has been fined two undecillion (a two followed by 36 zeroes) roubles by a…

4 days ago

Financing Your Home Remodel: 7 Tips for Success

Embarking on a home remodel is an exciting journey, promising enhanced comfort, increased property value,…

2 weeks ago

Donald Trump Serves Up McDonald’s Fries While Kamala Harris Celebrates 60th Birthday with Church Choir

The US presidential candidates continued to campaign across key swing states on October 20. Footage…

2 weeks ago