Subscribe to newsletter

UrbanObserver

https://demo.afthemes.com/newsphere/fashion/wp-content/uploads/sites/2/2019/04/cropped-af-themes-main-dark.png

Always Active
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.

No cookies to display.

Functional cookies help to perform certain functionalities like sharing the content of the website on social media platforms, collect feedbacks, and other third-party features.

No cookies to display.

Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors.

No cookies to display.

Analytical cookies are used to understand how visitors interact with the website. These cookies help provide information on metrics the number of visitors, bounce rate, traffic source, etc.

No cookies to display.

Advertisement cookies are used to provide visitors with relevant ads and marketing campaigns. These cookies track visitors across websites and collect information to provide customized ads.

No cookies to display.

Other uncategorized cookies are those that are being analyzed and have not been classified into a category as yet.

No cookies to display.

Tuesday, April 8, 2025
Home Blog Page 1206

Books industry is adapting to the e-books wave

 [googlead tip=”vertical_mare” aliniat=”dreapta”] The books industry has been upended by the expansion of the e-books, and publishers are shifting in opposition to tradition by publishing paperbacks books edition earlier than regular, occasionally less than 6 months after the book came out in hardcover.

It used to be a strict schedule in the books business: first the hardcover edition was printed, and about 12 months after that, the paperback book was published.

E-books have made cost a challenge for publishers and they are considering the right time of a paperback book. There is often a big distance between the price of a fresh hardcover book and its e-book edition. The paperback book and e-book tend to be within a couple of dollars, rendering numerous publishers to speculate if cost-conscious buyers are reading e-books right away instead of waiting for the paperbacks books.

Hardcover book has been the publishing style of the first option for a long time. Authors want to make an impression with their books release, so hardcover is the initial selection when publishing. If a person favors a paperback, he or she will get the book after a long delay.

Books
Books

A hardcover is likely to age far more softly. Paperbacks split, wrinkle and discolor much more quickly. Some people love to have a nice-looking bookshelf. Hardback book is more likely to appear great and even as apposed to a  wrinkly paperback book. Although the story contained in a book may be identical, some people will refuse to buy a book if it is not bound in their favored form.

Paperbacks books are generally less expensives than hardcovers. When the editor and author save money in the creation process, the discounts are transferred to the buyer.
Being able to effortlessly take a book with you is a great ease. Paperbacks are free of the extra weight and also free of the thickness of a hardcovers books.

Since the large, synchronised release of hardcover and electronic editions of a book currently gather the bulk of the attention the book is likely to get, letting the paperback book edition considerably in the back, publishers state they have a fresh sense of urgency with the paperback. 

 [googlead tip=”patrat_mare”] Last week involved the trade paperback release of “Swamplandia!”, a debut novel by Karen Russell, 5 months just after it was first printed in hardcover in February.

Anne Messitte, a publisher of Vintage/Anchor, said that when Vintage editors published the paperback of “Swamplandia!”, they chose July to capitalize on product sales to summertime travellers, who tend to favor fiction.
“It felt to us like a perfect summer paperback,” she stated about the book, that stories the imaginary ventures of a Florida family members threathened by alligators.

“The Tiger’s Wife,” a fictional book by Téa Obreht, that became available in hardcover in March, will be followed by the  paperback book  in October, 7 months later.

“Those Guys Have All the Fun: Inside the World of ESPN” by James Andrew Miller and Tom Shales, has hardly been in book shops two months, having showed up on May, and the  paperback book edition is already planned for December. Therefore, nonfiction release has been sped up as well.

The entire publishing daily life routine has sped up in recent years. Hardcovers books have less time in book shops, due to the fact the merchants tend to shift them off the shelves more quickly than they used to.

“E-book sales are usually strong in the initial period after the publication date but do not spike again after the paperback comes out”, said Terry Adams, the digital and paperback publisher for Little, Brown & Company.  [googlead tip=”lista_mare” aliniat=”dreapta”]
Terry Adams released the paperback of “Room,” a book by Emma Donoghue, 8 months after the hardcover book due to the fact hardcover product sales had slowed down but not ceased totally. “The momentum was there, and we wanted to capture the momentum for the paperback,” he said. “For books that rise to a certain level of visibility, you really want to ride the wave.”

However, there are still exceptions to the paperbacks books  timetable. A number of publishers said that the 12 months delay was still being the principle for most books. If a book is selling quickly in hardcover, publishers tend to postpone on releasing a paperback book edition. Stieg Larsson’s 3rd book in the Millennium series, “The Girl Who Kicked the Hornet’s Nest,” has not yet been printed in paperback edition in the United States, more than 12 months following the hardcover book was released.

Gabrielle Giffords’ vote – the most memorable out of 430

Gabrielle Giffords returned after seven months for her vote.

 

[googlead tip=”vertical_mediu” aliniat=”stanga”]The full number of votes on the historic debt-limit bill was 430.

One of the votes has been the most important one.

Gabrielle Giffords
Gabrielle Giffords

The republican Gabrielle Giffords returned to the House on Monday to cast her vote after 7 months since she was shot in the head. Lots of applause and hugs from Gabrielle Giffords Republican and Democratic colleagues greeted her.

Gabrielle Giffords’ entrance, with just minutes remaining in the vote, surprised lawmakers and added even more drama to a high-stakes day. The Arizona Democrat responded to the attention with a smile, and she mouthed “thank you” several times.

Gabrielle Giffords used one hand to greet people and the other one by her side. Gabrielle Giffords hair was dark and closely cropped, and she wore glasses.

 

Gabrielle Giffords cast her vote for the debt-limit bill, which finally passed 269 to 161.

 

“She is a model for the attitude that we should all have because she is tenacious and she is relentless in her love for America. … You were missed and we’re glad to have you back,”

said Republican Ted Poe, R-Texas.

Gabrielle Giffords exited the House chamber by the east door, leaning slowly on an aide as she stepped with obvious difficulty. Her husband, astronaut Mark Kelly, accompanied her. Police had cleared a path throughout hundreds of reporters, and Gabrielle Giffords did not respond to questions or greetings.

Close to the doorway to the House, Vice President Joe Biden greeted Gabrielle Giffords and marveled at her return.

“She’s remarkable. Will matters,”

Biden said in an interview.

 “She’s the embodiment of a strong, strong, strong woman. Think about what that woman’s been through, and think about her determination.”

 

On January 8,2011,  Gabrielle Giffords was shot in the head

 [googlead tip=”patrat_mare” aliniat=”stanga”]

in the parking area of a Tucson grocery store while meeting with constituents. Six persons have been killed and 13 others, including Gabrielle Giffords, were wounded. Jared Lee Loughner, the man charged in this event, was sent to a federal prison facility in Springfield, after a federal judge concluded he was mentally incompetent to stand trial on 49 charges.

At the moment Biden hugged Gabrielle Giffords, Republican presidential candidate Michele Bachmann, R-Minn., joined them.

“Sure, I like Michele Bachmann. We’re all standing there and Michele walks up to see Gabby, because she cares about her,”

 Biden said.

Gabrielle Giffords issued a news release after the vote — the only thing typical in an atypical day.

“I have closely followed the debate over our debt ceiling and have been deeply disappointed at what’s going on in Washington,” Gabrielle Giffords said in the statement.

“I strongly believe that crossing the aisle for the good of the American people is more important than party politics. I had to be here for this vote. I could not take the chance that my absence could crash our economy,”

Gabrielle Giffords also said.

[googlead tip=”lista_mare” aliniat=”stanga”]

Gabrielle Giffords return

Ashley Hebert has picked her man

[googlead tip=”vertical_mediu” aliniat=”dreapta”] Ashley Hebert, the latest Bachelorette, has chosen her match made in heaven on Tv network.

The last man standing on the ABC relationship reality show “The Bachelorette” is J.P. Rosenbaum from New York’s Long Island.

Ashley Hebert selected the 34-year-old construction manager over winemaker Ben Flajnik from California in Monday’s two-hour finale.

Ashley Hebert accepted Rosenbaum’s proposal on the show.

 

Ashley Hebert
Ashley Hebert


Ashley Hebert, 26, is a Maine native.

Ashley Hebert now lives in Philadelphia and attends dental care school.

Until now, two couples from “The Bachelor” and “The Bachelorette” franchise have made it down the church

aisle.

Two guys proposed Ashley Hebert on Monday’s finale:winemaker Ben Flajnik, 28, and New York construction manager J.P. Rosenbaum, 34. 

From the beginning, Ashley Hebert had an amazing connection to Flajnik and she was more reserved with regard to Rosenbaum who finaly captured her heart.

After refusing Flajnik’s heartfelt proposal in which he confessed,

“Every second I spend with you makes me fell deeper in love with you. I want to thank you for allowing me to feel completely and utterly vulnerable and open with you,”

[googlead tip=”lista_mica” aliniat=”stanga”]

 

Ashley Hebert waited for Rosenbaum’s arrival via seaplane.

Once J.P. Rosenbaum arrived, neither he nor Ashley Hebert could contain their happiness.

“All the time we’ve spent together, it’s been the happiest time of my life,”

said J.P.Rosenbaum.

 “And you always say to me you’re smiling all the time, you’re going to have wrinkles when you’re older. Well, I smile because of you. You bring that out. What I do know for absolute certain is that I am madly in love with you. I love everything about you.”

After a passionate kiss, Ashley Hebert tells him:

 “Today is the reason why I went through all the good times and the bad times, and I’ve been wanting to tell you how much I loved you for so long now. You mean the world to me and I do not want to be with anyone else forever.”

[googlead tip=”patrat_mediu” aliniat=”dreapta”]

“I’m so in love with you. You’re the one. You’re it,” 

Rosenbaum said , getting down on one knee and opening the  little black box containing a diamond Neil Lane engagement ring.

 “Ashley Hebert, will you marry me?” 

 

Ashley Hebert said “Yes!”

bending down to kiss J.P. Rosenbaum while he placed the ring on her finger. Ashley Hebert  and her man kissed, and kissed, and kissed, as they lost themselves into the Fijian sunset…

Randy Moss – is he retiring?

Will certainly Randy Moss retire instead to suit up for a 14th National football league (NFL) season?

Joel Segal, Randy Moss‘ agent, informed NFL Network and ESPN of his client’s choice. He told that the receiver was thinking about offers from several clubs, but decided to retire. Segal declined to comment particularly on the offers, rather declaring his 34 yo client sensed the time was right to step aside.  [googlead tip=”lista_mare” aliniat=”dreapta”]

Randy has weighed his options and considered the offers and has decided to retire,” Segal said.

Randy Moss was typically connected to the New York Jets as a destination for this year, but they signed WR Plaxico Burress yesterday.
Randy Moss performed for three teams in 2010 — he was traded from New England to Minnesota last October, waived by the Vikings in November previous to concluding with Tennessee — and had his minimum successful period (28 catches, 393 yards, 5 touchdowns).

Randy Moss
Randy Moss

“I don’t want to say he was the best ever deep threat, because a threat is something you make without doing something. He did it,” Hall-of-Fame WR James Lofton, who knows a lot regarding stretching the field, shared with USA TODAY’s Robert Klemko.

His 153 touchdowns are tied with Terrell Owens for second on the career list, and he’s also fifth in yards (14,858) and tied with Hines Ward for eighth in receptions (954).
These statistics, and his position, as perhaps the greatest strong menace in National Football League (NFL) historical past, is likely to make him a strong candidate for the Hall of Fame.

[googlead tip=”vertical_mare” aliniat=”dreapta”]His career began with 7 seasons with the Minnesota Vikings prior to he went inactive for two years in Oakland. He re-emerged as a force with the New England Patriots in 2007, lifting in a single-season record 23 touchdowns passes from Tom Brady in order to assist the Patriots reach the Super Bowl.
Randy Moss was a first-round choose of Marshall in 1998, obtained twenty-first general. However, worries concerning his off-field habits avoided him from going much sooner. He reacted by winning offensive rookie of the year honorsdeemed the best rookie season at any time by NFL Network.
Randy has been a great player for a long time,” said Bob Pruett, Randy Moss‘ college coach at Marshall. ”He’s choosing this on his own terms and I think that’s good. If that’s what he wants to do, that’s what he should do.”

 In the course of his career, Randy Moss gained the reputation as one of the most dangerous players in the game, when he wanted to be.

His combination of dimensions, velocity and cleverness has hardly ever been seen for a player at his position, and he should get some credit for the increase of two defenses throughout the National Football League that were designed in large part to prevent Randy Moss from burning them down the field.
“His body control, his ability to slow himself, elevate, and position himself is unbelievable, better than anybody I’ve ever seen play the game… He had a phenomenal presence on the football field. He was a player that defenses had to adjust to and really didn’t do a very good job of it” said Lofton.

Vikings supporters were euphoric at the news of his returning last season. Randy Moss caught 13 passes for 174 yards and two touchdowns in 4 games back in purple, clashed with Childress in the locker room and turned some co-players off with his inadequate treatment of a team caterer towards the end of his run. He hugged former Patriots teammates after a Vikings loss, and then strangely walked to a podium to fuss over the Patriots, upbraid the Vikings for neglecting his strategic guidance, and declare his strategy to interview himself the rest of the season rather than allowing reporters do it. [googlead tip=”patrat_mare”]

One of  Randy Moss‘ former co-player believes he’s got enough of that capability remaining that he will in fact pull back (Brett Favre Randy Moss‘ quarterback shortly  in 2010) and unretire.
“He’s as talented a guy as I’ve ever seen play the game. He’s a guy with some pride, and more than anything else in the past few years he’s thinking about his legacy,” said ESPN analyst Robert Smith, who played with Randy Moss on the Vikings from 1998-2000.

Brandon Marshall diagnosed with Borderline Personality Disorder

Early-onset dementia: symptoms and the importance of early diagnosis.

 

Bipolar disorder: new hope from stem cell research.

 

[googlead tip=”vertical_mediu” aliniat=”dreapta”]

Brandon Marshall is an exceptionally gifted wide receiver whose private daily life and off-the-field tricks have got generally attracted way more interest that his touchdown grabs or third down conversions. He informed us yesterday that he was diagnosed with Borderline Personality Disorder.

Marshall appreciates he has got it all: National football league, wealth, a smart, attractive spouse, a beautiful house, an excellent life – almost everything any person may possibly would like. But it wasn’t sufficient. It was never good enough.

Brandon Marshall
Brandon Marshall

 

But now we know the reason why: the All-Pro seated for 30 minutes along with journalists following training yesterday and stated he was diagnosed with Borderline Personality Disorder earlier this year.

Miami Dolphins’ wide receiver has borderline personality disorder and, rather than disguising that fact, he’s choosing to “be the face of Borderline Personality Disorder (BPD).” Marshall spoke openly about it over the past weekend, informing the Sun-Sentinel: 

  [googlead tip=”lista_mare” aliniat=”centrat”]

I’ll make myself vulnerable if it saves someone’s life because I know what I went through this summer helped save mine.”

Brandon Marshall had experienced therapy several times prior to this.

Now, at the proposition of Dolphins teammate Ricky Williams, Marshall looked for support from McLean Hospital in Boston.

Marshall attained day-to-day together with specialists and other Borderline Personality Disorder (BPD) sufferers.

Any time there’s conflict it’s a challenge,” Marshall explained. “What I’m feeling or trying to get across is right, but I’m reacting wrong. My actions or what I’m saying is not effective or productive and it makes the situation worse.”

By means of therapy, he is learning to deal with his sentiments and emotions.

By no means am I all healed or fixed,” he said, “but it’s like a light bulb’s been turned on in my dark room.”

 [googlead tip=”patrat_mediu” aliniat=”stanga”]

Borderline Personality Disorder is seldom diagnosed. It is noticeable by difficulties with human relationships, inadequate self-image as well as difficulty managing emotional behavior and sensations. Marshall has spoken about his stressed child years and desertion and abuse that can contribute to BPD. Mary Zanarini – the professor of psychology at Harvard Medical School who treated Marshall this summer – declared to The South Florida Sun-Sentinel:

BPD is a well understood psychological disorder. It’s not a form of misbehavior.

Brandon Marshall mentioned he plans to lobby Congress for finances to assist study into the condition, adding:

There comes a time in a guy like myself’s life, with everything that I’ve been through, that you become bulletproof to the critics and to what the world thinks of you. Right now, today, I am vulnerable. I am making myself vulnerable. And I want it to be clear that this is the opposite of damage control. The only reason why I’m standing here today is to use my story to help others who may suffer from what I suffer from.”

Selena and Justin – are they breaking up ?

Selena Gomez owns the sold-out audience shouting, singing along out loud, as well as waving paper prints with her name every time she goes on the stage. She’s young and she’s beautiful.

A picture with Justin Bieber performing Justin Timberlake’s “Cry Me a River” makes the tween young ladies go nuts.

[googlead tip=”patrat_mediu” aliniat=”stanga”]  Whilst gossip flow that Justin Bieber and Selena have broken up over a text message Bieber sent to his sweetheart. In a current interview with Contact Music, Gomez stated her romantic relationship with Bieber is actually “all good” although the girl has got zero motives to get married to him.

“No, I’m only 19!” the girl explained when questioned if she will marry the guy someday. Bieber pleasantly surprised admirers, accompanying Selena on stage throughout the girls premier performance on July 25, when he performed Justin Timberlake’s Cry me a River along with his own track, “Favorite Girl”. Soon after, he wrote on tweeter,

“‘Had a great night and surprised the people. felt good to be on stage. nothing is changing that. REAL. @selenagomez u did great tonight. proud of u.”

 [googlead tip=”vertical_mare” aliniat=”dreapta”]

Selena Gomez and Justin Bieber
Selena Gomez and Justin Bieber

 

On Thursday, Selena’s boyfriend showed up to support her at the kickoff concert in Boca Raton. But the guy was not on hand on Friday when the girl checked out the actual Wizarding World of Harry Potter at Universal. However, she managed  to enjoy herself lacking him.

She was in fact joined by Ashley Cook, Lindsey Harper as well as Katelyn Clampett as the group sipped on Butterbeer and met the Conductor at Hogwarts Express. They also rode the Hungarian Horntail coaster on Dragon Challenge, which must have been a lot of fun.
Afterwards, Selena tweeted,

“First day off in Harry Potter Land we my girls in Orlando Florida. Having some butter beer. [sic]” 

Apparently, she is taking her time to rest and enjoy herself in between her tour concerts. [googlead tip=”lista_mare” aliniat=”dreapta”]

Let’s not forget about Justin Bieber.  We must ask: What was the reason for choosing “Cry Me a River” out of the many unforgettable and jam-worthy tunes Justin Timberlake has as part of his repertoire? Since you may recall, “Cry Me a River” seemed to be J.T.’s response to his separation with Brit. Perhaps there is something he’s trying to tell Ms. Selena Gomez.
We hope Selena does not go the same way as Brit and Justin.

DB Cooper : Newest updates on his pursuit

Following hijacking the aircraft and also requesting ransom two hundred thousand from the Federal bureau of investigation, DB Cooper made a ambitious evade through the use of parachute.

Forty years afterwards, brand new proof suggests the authorities may finally be hot on the path of America’s most mysterious fugitive. Nevertheless what are the latest facts?

DB Cooper
DB Cooper

 [googlead tip=”lista_mare” aliniat=”dreapta”] Around the night before Thanksgiving of 1971, a guy who named himself Dan Cooper (a press reporter being employed by among the many wire assistance misheard the name of the hijacker, and ever since then he has been referred to as D.B. Cooper, as an alternative to Dan) dressed in a suit and raincoat, wandered up to the Northwest Orient desk at Portland’s airport and spent $20 on a one-way ticket to Seattle.

On the flight, he used some dark sunglasses, purchased a whiskey, lit up a cigarette and coolly given the stewardess some text. In capital letters, DB Cooper’s note read:

I HAVE A BOMB IN MY BRIEFCASE. I WILL USE IT IF NECESSARY. I WANT YOU TO SIT NEXT TO ME. YOU ARE BEING HIJACKED.

Just what happened next would give Cooper the place in the pantheon of US folk heroes.  [googlead tip=”patrat_mare”]

D.B. Cooper requested the stewardess to inform the next require to the plane’s captain: he wanted $200,000 and a number of parachutes, and in return, he’d allow 36 people to leave the aircraft as soon as the plane arrived in Seattle. The FBI, swiftly called by ground control, organized the swap, and when the airplane was sky-bound again, with only the pilot, co-pilot, one stewardess and DB Cooper on board. 

The hijacker’s directions were to head for Mexico, keeping an altitude under 10,000 feet. Then, somewhere above the lower Cascade mountains, 25 miles north west of Portland, D.B. Cooper launched the plane’s aft stairs, stepped out, and, with one of the parachutes strapped to his back, jumped into the raining, cold November night and has been never seen or observed from again. [googlead tip=”vertical_mare” aliniat=”dreapta”]

By the moment military helicopters were scrambled, on November 24th 1971, to search the land north of Portland for a six-foot-tall white man weighing one hundred seventy to a hundred seventy five pounds, “DB” Cooper was long gone – most probably possibly dead or packing away his parachute and trudging through mud and rain to make his escape.

Over the previous 40 years since that chilly night, there have been more than 1,000 DB Cooper suspects, a number of deathbed confessions, a film (starring Robert Duvall), as well as well more than a dozen books. As one person told legendary Cooper tracker Alex Hannaford, DB Cooper is the “Bigfoot of the Pacific Northwest.”

Kings of Leon interrupted a concert Friday in Dallas

Kings of Leon interrupted a concert Friday in Dallas, Texas subsequent to guide performer Caleb Followill informed admirers, “I’m going to move behind the scenes and I’m gonna vomit, I’m gonna drink a beer and I’m gonna come back out and play three more songs.”

The rocker by no means came back to the stage, that pushed the other members of this rock band to say sorry to the viewers. “Caleb’s just a little unfit to play the rest of the show,” explained bassist Jared Followill. “We love you guys so much, but I know you guys fucking hate us. I’m so sorry. It’s really not our fault, it’s Caleb. He can’t play the rest of the show. We will be back as soon as possible.”

Kings of Leon
Kings of Leon

 

 

Even though Caleb Followill has revealed that the cause he quit the stage was because of heat, fatigue and also lack of fluids, his sibling Jared’s remarks on Twitter after the episode suggest that Caleb’s tendencies may be part of a larger issue in the music group. Soon after apologizing again, Jared published “there are internal sicknesses & problems that have needed to be address” and also “I know you guys aren’t stupid. I can’t lie. There are problems in our band bigger than not drinking enough Gatorade.”

This is a common endeavor that other bands are also pursuing. It’s not unusual for singers and other band members to have health problems or other issues which prevent them from singing. Caleb’s problem was health related but we cannot say for sure if that was the only reason for his behavior. 

 

 

 

 

Please view the video below which shows Caleb Followill talking to the audience at the Dallas concert. The video clip also displays footage of the other members of Kings of Leon apologizing him for his sudden departure.

Telomere progressive shortening characterizes familial breast cancer

Prostate cancer: a new treatment option from Swedish Lund University researchers.

 [googlead tip=”patrat_mare” aliniat=”stanga”]

Zelboraf for metastatic melanoma approved by FDA.

 

Potential breakthrough in cancer research: a new treatment for leukemia had amazing results.

 

Hereditary cancer: future methods of diagnosis and treatment

 

Progressive telomere shortening characterizes familial breast cancer patients

Telomere chromosome
Telomere chromosome

 

Telomeres, the complex structures that protect the end of chromosomes, of peripheral blood cells are significantly shorter in patients with familial breast cancer than in the general population. Results of the study carried out by the Human Genetics Group of the Spanish National Cancer Research Centre (CNIO), led by Javier Benitez, to be published in open-access journal PLoS Genetics on July 28th, reflect that familial, but not sporadic, breast cancer cases are characterized by shorter telomeres. Importantly, they also provide evidence for telomere shortening as a mechanism of genetic anticipation, the successively earlier onset of cancer down generations.

Mutations in two DNA repair genes, BRCA1 and BRCA2, characterize some, but not all, instances of hereditary breast cancer. Non-BRCA1/2 breast cancer families are heterogeneous, suggesting the existence of other genes conferring susceptibility. The group has investigated the role of telomere length in hereditary breast cancer based on previous information suggesting, first, that short telomeres and subsequent genomic instability contribute to malignant transformation; second, that genetic anticipation occurs in breast cancer families and, third, that telomere shortening is associated with anticipation in other genetic diseases. [googlead tip=”vertical_mare” aliniat=”stanga”]

By analyzing telomere length differences between mothers and daughters from breast cancer families, the authors demonstrated that genetic anticipation is associated with a decrease in telomere length in affected daughters relative to their mothers.

The results allowed the authors not only to conclude that women carrying BRCA1/2 mutation have chromosomes with short telomeres, but also to describe for the first time that genetic anticipation in breast cancer could be explained by telomere shortening. In addition, the study expands the field of research concerning genetic predisposition to breast cancer to include genes involved in telomere maintenance. The significance of generational changes in telomere length has interesting potential clinical applications in the management of familial breast cancer, and could be extended to other hereditary cancer syndromes.

###

FINANCIAL DISCLOSURE: This work was supported by Asociación Española Contra el Cancer (AECC) and Spanish Fondo de Investigaciones Sanitarias (grant numbers FISPI081298 and FIS-PI081120). The CIBER de Enfermedades Raras is an initiative of the ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

COMPETING INTERESTS: The authors have declared that no competing interests exist.

CITATION: Martinez-Delgado B, Yanowsky K, Inglada-Perez L, Domingo S, Urioste M, et al. (2011) Genetic Anticipation Is Associated with Telomere Shortening in Hereditary Breast Cancer. PLoS Genet 7(7): e1002182. doi:10.1371/journal.pgen.1002182

Contact:  
Dr. Beatriz Martinez-Delgado and Dr. Javier Benitez
Spanish National Cancer Research Centre (CNIO)
Human Genetics
Melchor Fernandez Almagro 3
Madrid 28029
SPAIN
bmartinez@cnio.es
jbenitez@cnio.es

Disclaimer  

This press release refers to an upcoming article in PLoS Genetics. The release is provided by journal staff, or by the article authors and/or their institutions. Any opinions expressed in this release or article are the personal views of the journal staff and/or article contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the releases and articles and your use of such information.

About PLoS Genetics

 [googlead tip=”lista_medie” aliniat=”stanga”]PLoS Genetics (http://www.plosgenetics.org) reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology. All works published in PLoS Genetics are open access. Everything is immediately and freely available online throughout the world subject only to the condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.  [googlead tip=”lista_medie” aliniat=”centrat”]

About the Public Library of Science

The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world’s scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org.

Potential breakthrough in cancer research: a new treatment for leukemia had amazing results.

Vince Young: Young was released and is about to become backup quarterback in Philadelphia.

Albert Breer of the NFL Network informs us via twitter that his team has reached an agreement with former Titan Vince Young. This is almost two years to this date, when the Eagles acquired former No. 1 draft pick Michael Vick.

“Looking forward to working with him,” Vick said of Vince Young, via CSNPhilly.com. “We’ll spend a lot of time getting to know one another. It’s cool – I look forward to having him in here, look forward to making him a better player.”

Vince Young
Vince Young
Vince Young might certainly become familiar with a point or two through Vick: Vick offers figured out how to be a trusted passer along with having other-worldly operating ability, and Vick has become a college student of the sport as well as group leader rather than a guy who believes his organic skill means he or she doesn’t need to work hard.

Vince Young, 2006 through 1st game of 2008 before injury and losing job to Collins: 57.3% completions, 6.41 yards per attempt, 22 TD to 32 INT, 6.4% sack rate  

Vince Young, since regaining job in 2009 until incident last year following thumb injury: 59.0% completions, 7.55 yards per attempt, 20 TD to 10 INT, 5.0% sack rate

 

Vince Young | Quarterback   [googlead tip=”patrat_mic” aliniat=”dreapta”]

Team:  Philadelphia Eagles
Ht / Wt:   6’5′ / 232
Age / DOB:   (28) / 5/18/1983
College:  Texas
7/29/2011: Signed a one-year contract.

 

 [googlead tip=”vertical_mare” aliniat=”dreapta”]

[googlead tip=”lista_medie” aliniat=”dreapta”]

Wishing good luck to Vince Young in his new position.