Kings of Leon interrupted a concert Friday in Dallas, Texas subsequent to guide performer Caleb Followill informed admirers, “I’m going to move behind the scenes and I’m gonna vomit, I’m gonna drink a beer and I’m gonna come back out and play three more songs.”
The rocker by no means came back to the stage, that pushed the other members of this rock band to say sorry to the viewers. “Caleb’s just a little unfit to play the rest of the show,” explained bassist Jared Followill. “We love you guys so much, but I know you guys fucking hate us. I’m so sorry. It’s really not our fault, it’s Caleb. He can’t play the rest of the show. We will be back as soon as possible.”
Kings of Leon
Even though Caleb Followill has revealed that the cause he quit the stage was because of heat, fatigue and also lack of fluids, his sibling Jared’s remarks on Twitter after the episode suggest that Caleb’s tendencies may be part of a larger issue in the music group. Soon after apologizing again, Jared published “there are internal sicknesses & problems that have needed to be address” and also “I know you guys aren’t stupid. I can’t lie. There are problems in our band bigger than not drinking enough Gatorade.”
This is a common endeavor that other bands are also pursuing. It’s not unusual for singers and other band members to have health problems or other issues which prevent them from singing. Caleb’s problem was health related but we cannot say for sure if that was the only reason for his behavior.
Please view the video below which shows Caleb Followill talking to the audience at the Dallas concert. The video clip also displays footage of the other members of Kings of Leon apologizing him for his sudden departure.
Progressive telomere shortening characterizes familial breast cancer patients
Telomere chromosome
Telomeres, the complex structures that protect the end of chromosomes, of peripheral blood cells are significantly shorter in patients with familial breast cancer than in the general population. Results of the study carried out by the Human Genetics Group of the Spanish National Cancer Research Centre (CNIO), led by Javier Benitez, to be published in open-access journal PLoS Genetics on July 28th, reflect that familial, but not sporadic, breast cancer cases are characterized by shorter telomeres. Importantly, they also provide evidence for telomere shortening as a mechanism of genetic anticipation, the successively earlier onset of cancer down generations.
Mutations in two DNA repair genes, BRCA1 and BRCA2, characterize some, but not all, instances of hereditary breast cancer. Non-BRCA1/2 breast cancer families are heterogeneous, suggesting the existence of other genes conferring susceptibility. The group has investigated the role of telomere length in hereditary breast cancer based on previous information suggesting, first, that short telomeres and subsequent genomic instability contribute to malignant transformation; second, that genetic anticipation occurs in breast cancer families and, third, that telomere shortening is associated with anticipation in other genetic diseases. [googlead tip=”vertical_mare” aliniat=”stanga”]
By analyzing telomere length differences between mothers and daughters from breast cancer families, the authors demonstrated that genetic anticipation is associated with a decrease in telomere length in affected daughters relative to their mothers.
The results allowed the authors not only to conclude that women carrying BRCA1/2 mutation have chromosomes with short telomeres, but also to describe for the first time that genetic anticipation in breast cancer could be explained by telomere shortening. In addition, the study expands the field of research concerning genetic predisposition to breast cancer to include genes involved in telomere maintenance. The significance of generational changes in telomere length has interesting potential clinical applications in the management of familial breast cancer, and could be extended to other hereditary cancer syndromes.
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FINANCIAL DISCLOSURE: This work was supported by Asociación Española Contra el Cancer (AECC) and Spanish Fondo de Investigaciones Sanitarias (grant numbers FISPI081298 and FIS-PI081120). The CIBER de Enfermedades Raras is an initiative of the ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
COMPETING INTERESTS: The authors have declared that no competing interests exist.
CITATION: Martinez-Delgado B, Yanowsky K, Inglada-Perez L, Domingo S, Urioste M, et al. (2011) Genetic Anticipation Is Associated with Telomere Shortening in Hereditary Breast Cancer. PLoS Genet 7(7): e1002182. doi:10.1371/journal.pgen.1002182
Contact: Dr. Beatriz Martinez-Delgado and Dr. Javier Benitez Spanish National Cancer Research Centre (CNIO) Human Genetics Melchor Fernandez Almagro 3 Madrid 28029 SPAIN [email protected] [email protected]
Disclaimer
This press release refers to an upcoming article in PLoS Genetics. The release is provided by journal staff, or by the article authors and/or their institutions. Any opinions expressed in this release or article are the personal views of the journal staff and/or article contributors, and do not necessarily represent the views or policies of PLoS. PLoS expressly disclaims any and all warranties and liability in connection with the information found in the releases and articles and your use of such information.
About PLoS Genetics
[googlead tip=”lista_medie” aliniat=”stanga”]PLoS Genetics (http://www.plosgenetics.org) reflects the full breadth and interdisciplinary nature of genetics and genomics research by publishing outstanding original contributions in all areas of biology. All works published in PLoS Genetics are open access. Everything is immediately and freely available online throughout the world subject only to the condition that the original authorship and source are properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License. [googlead tip=”lista_medie” aliniat=”centrat”]
About the Public Library of Science
The Public Library of Science (PLoS) is a non-profit organization of scientists and physicians committed to making the world’s scientific and medical literature a freely available public resource. For more information, visit http://www.plos.org.
Potential breakthrough in cancer research: a new treatment for leukemia had amazing results.
Albert Breer of the NFL Network informs us via twitter that his team has reached an agreement with former Titan Vince Young. This is almost two years to this date, when the Eagles acquired former No. 1 draft pick Michael Vick.
Vince Young might certainly become familiar with a point or two through Vick: Vick offers figured out how to be a trusted passer along with having other-worldly operating ability, and Vick has become a college student of the sport as well as group leader rather than a guy who believes his organic skill means he or she doesn’t need to work hard.
Vince Young, 2006 through 1st game of 2008 before injury and losing job to Collins: 57.3% completions, 6.41 yards per attempt, 22 TD to 32 INT, 6.4% sack rate
Vince Young, since regaining job in 2009 until incident last year following thumb injury: 59.0% completions, 7.55 yards per attempt, 20 TD to 10 INT, 5.0% sack rate
Vince Young | Quarterback [googlead tip=”patrat_mic” aliniat=”dreapta”]
Team:
Philadelphia Eagles
Ht / Wt:
6’5′ / 232
Age / DOB:
(28) / 5/18/1983
College:
Texas
7/29/2011:
Signed a one-year contract.
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Wishing good luck to Vince Young in his new position.
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