As FDA pulled cantaloupes from the shelves due to possible health risk, many of consumers may be left with questions about listeriosis, here are some facts from the U.S. Centers for Disease Control and Prevention (CDC) website. The listeriosis cases have been reported in five states in U.S.
What Is Listeriosis?
Listeriosis is a serious infection caused by eating food contaminated with the bacterium Listeria monocytogenes. It primarily affects older adults, pregnant women, newborns and adults with weakened immune systems. Rarely, persons without these risk factors can be infected.
What Are the Symptoms of Listeriosis? How Is It Diagnosed and Treated?
A person with the infection usually has a fever, muscle aches, headache, stiff neck, confusion, loss of balance and convulsions often preceded by diarrhea or other gastrointestinal symptoms. Pregnant women typically experience flulike illness but infections during pregnancy can lead to miscarriage, stillbirth, premature delivery or infections in the newborn.
The CDC says that an estimated 1,600 people become seriously ill with listeriosis every year and of these people, 260 die. A blood or spinal fluid test to look for the bacteria is used to diagnose the infection. Antibiotics given promptly can cure the illness and prevent infection in the fetus. Even with treatment, some infections can lead to death especially in at-risk adults.
How Do People Get Listeriosis?
Listeria is found in soil, water and foods of animal origin. Listeria bacteria can live in a food processing factory for years. It’s been found in uncooked meats and vegetables; soft cheeses; processed meats like hot dogs and deli meat; and smoked seafood. Unpasteurized raw milk and cheeses are likely to contain the bacterium as well.
You get listeriosis by eating food contaminated with Listeria. Babies can be born with listeriosis if their mothers ate food contaminated with Listeria during pregnancy. Unlike most bacteria, Listeria can grow and multiply in some food in the refrigerator.
CDC Tips to Prevent Listeriosis:
• If you’re considered at risk, avoid high-risk foods and handling food properly.
• Thoroughly cook raw food from animal sources, such as beef, pork or poultry to a safe internal temperature.
• Rinse raw vegetables thorougly under running water before eating.
• Keep uncooked meats and poultry separate from vegetables and from cooked foods and ready-to-eat foods.
• Do not drink raw and unpasteurized milk and do not eat foods that have unpasteurized milk in them.
• Wash hands, utensils, countertops and cutting boards after handling and preparing uncooked foods.
• Consume perishable and ready-to-eat foods as soon as possible.
• Be aware that Listeria can grow in foods in the refrigerator.
• Clean up spills in your refrigerator right away.
• Clean the inside walls and shelves of your refrigerator with hot water and liquid soap and then rinse.
• Divide leftovers into shallow containers for fast, even cooling.
The FDA announced a recall today for cantaloupes from Jensen Farms, after the Colorado company confirmed that one of its Rocky Ford melons had tested positive for the bacterium Listeria.
A Jensen Farms spokeswoman said today that more tests would be needed to determine whether the strain found in its produce was linked to two confirmed deaths and 16 cases of listeriosis, a potentially deadly infection, The Associated Press reported.
FDA recalls Jansen Farms cantaloupe
Amy Philpott, Jensen Farms representative said the farm had shipped more than 300,000 cases across the U.S. between July 29 and September 10 and has recalled the entire harvest.
The U.S. Centers for Disease Control and Prevention (CDC) said that it was the first Listeria outbreak tied to cantaloupe in the U.S.
The listeriosis cases have been reported in five states and Colorado authorities have told retailers to remove Jensen Farms’ cantaloupes from the shelves.
It was also reported that a couple from Denver was expected to file the first lawsuit related to the listeriosis outbreak after the husband ate a Jensen cantaloupe and got sick. The man tested positive for listeriosis and remains hospitalized.
“Jensen Farms continues to stay committed to the highest levels of food safety and maintains many third party safety audits, as we have for many years. We continually look for ways to enhance our protocol,” said Ryan Jensen, partner at Jensen Farms.
FOR IMMEDIATE RELEASE – September 14, 2011 – Jensen Farms, of Holly, CO is voluntarily recalling their shipments of Rocky Ford whole cantaloupe because they have the potential to be contaminated with Listeria. The company is working with the State of Colorado and the FDA to inform consumers of this recall. L. monocytogenes is a bacterium that can contaminate foods and cause a mild non-invasive illness (called listerial gastroenteritis) or a severe, sometimes life-threatening, illness (called invasive listeriosis). Persons who have the greatest risk of experiencing listeriosis after consuming foods contaminated with L. monocytogenes are fetuses and neonates who are infected after the mother is exposed to L. monocytogenes during pregnancy, the elderly, and persons with weakened immune systems.
The whole cantaloupes in question were shipped between July 29th, 2011 and September 10th 2011, and distributed to the following states: IL, WY, TN, UT, TX, CO, MN, KS, NM, NC, MO, NE, OK, AZ, NJ, NY, PA. The whole cantaloupes have a green and white sticker that reads: Product of USA- Frontera Produce-Colorado Fresh-Rocky Ford-Cantaloupe or a gray, yellow, and green sticker that reads: Jensen Farms-Sweet Rocky Fords. If the whole cantaloupe is unlabeled, please contact your retail store for sourcing information. Jensen Farms is requesting any consumer that many have one of these cantaloupes to please destroy the products.
The recall involves only whole cantaloupe shipped by Jensen Farms, and no other commodities are involved. Jensen Farms feels it is prudent to participate in the recall as the State of Colorado has stated (in their September 12th, 2011 press release) that people at a high risk for infection should not eat whole cantaloupe from the Rocky Ford growing region.
“Jensen Farms continues to stay committed to the highest levels of food safety and maintains many third party safety audits, as we have for many years. We continually look for ways to enhance our protocol,” said Ryan Jensen, partner at Jensen Farms. Jensen Farms is a 3rd generation family farm of the Holly, Colorado community.
Consumers with questions may contact Jensen Farms via email at [email protected] or phone 1-800-267-4561 between the hours of 9am and 4pm MST.
The risk of diabetes type 2 is higher for persons who are living long time with overweight or obesity, said researchers from University of Michigan, Ann Arbor and St Jude Children’s Research Hospital, Memphis, Tennessee.
Long term obesity lead to higher risk of diabetes
The medical scientists made a survey of 8157 adolescents and young adults (aged 14 to 21 years in 1979) from 1981 until 2006. The patients had self-reported measures of height, weight, and diabetes status (type unspecified). The scientists conducted logistic regression models to predict presumed type 2 diabetes (after excluding presumed type 1 diabetes).
Joyce M. Lee, Achamyeleh Gebremariam, Sandeep Vijan, James G. Gurney discovered that the degree and duration of excess weight, or obesity was a better predictor of diabetes risk than a single measurement of excess weight.
“Our study finds that the relationship between weight and type 2 diabetes is similar to the relationship between smoking and the risk of lung cancer. The amount of excess weight that you carry and the number of years for which you carry it dramatically increase your risk of diabetes,” said Joyce Lee, pediatric endocrinologist.
Children are becoming overweight or obese earlier, they are carrying extra weight for longer periods. “When you add the findings from this study, rates of diabetes in the United States may rise even higher than previously predicted,” Dr Lee said.
The researchers, who published their findings in September issue of Pediatric Adolescent Medicine, said people with a BMI of 35 for 10 years would be considered to have 100 years of excess BMI. White men aged 40 years with 200 excess BMI-years had 2.94 times higher odds of developing diabetes compared with men of the same age and race with 100 excess BMI-years. For a given level of excess BMI-years, younger compared with older and Hispanic and black compared with white had higher risk of developing diabetes. Yet the study is limited by use of self-reported data without specification of diabetes type.
Diabetes type 2 is a metabolic disorder with high blood glucose, insulin resistance and relative insulin deficiency. Long-term complications from high blood sugar: heart attacks, strokes, amputation, diabetic retinopathy, kidney failure, loss of hearing, eyesight, cognitive ability. Diabetes, often found in persons with obesity, is manageable through exercise and diet, later oral medication (pills) might be necessary, or even insulin.
What is obesity in adults and in children? Overweight and Obesity Definition
Obesity in adults is evaluated through BMI, its duration correlates with diabetes type 2 risk
Overweight and obesity designate the weight values over what is accepted to be healthy for a given height. These terms also name ranges of weight that increase the risks of health problems. For adults, overweight and obesity are determined by calculating body mass index (BMI). BMI is calculated using weight and height. This index is used because, for most people, it correlates with their amount of body fat. A BMI over 25 is considered overweight, and a BMI over 30 is considered obese. BMI ranges for children and teens take into account normal differences in body fat between boys and girls and differences in body fat at various ages.
According to CDC 33.8% of U.S. adults are obese and around 17% (or 12.5 million) of children and adolescents are obese.
In 2010, all states had a prevalence of obesity over 20%, 36 states had a prevalence of 25% or more; 12 of these states (Alabama, Arkansas, Kentucky, Louisiana, Michigan, Mississippi, Missouri, Oklahoma, South Carolina, Tennessee, Texas, and West Virginia) had a prevalence of 30% or more.
Weight loss is a remedy to lots of obesity related health problems.
The outbreak of listeriosis, an illness caused by the food-borne pathogen Listeria, has killed 5 people and sickened many others across at least six states in US following the consumption of cantaloupe.
Three of the five deaths that have been attributed to Listeria contamination were in New Mexico, and people in Colorado, Texas and Nebraska were also infected following the consumption of cantaloupe.
Rocky Ford cantaloupe is the likely culprit of Listeria infection
Listeria infection is generally contracted from deli meats and hot dogs, and can result from consumption of dairy as well.
The higher risk of Listeria infection is among the elderly, small children, people with compromised immune systems and particularly pregnant women, who risk a miscarriage or stillbirth from exposure to the pathogen.
A person who comes down with Listeria infection usually experiences fever, muscle aches, diarrhea and confusion. The infection almost always spreads to the gastrointestinal tract, but can also cause miscarriages and stillbirths in pregnant women.
Two of the five deaths, which have been related to Listeria infection, occurred in Colorado, and public health officials believe they may have traced the outbreak to “cantaloupe from the famed Rocky Ford area” as the “likely culprit” of the severe illnesses and deaths.
US Centers for Disease Control and Prevention issued a cantaloupe warning after 16 cases of a strain of Listeria were reported in five states, including 11 from Colorado, two from Texas, and one each from Indiana, Nebraska and Oklahoma.
The agency said it was the first Listeria outbreak linked to cantaloupe in the United States. The US Food & Drug Administration said it had not recalled the cantaloupes while it worked to locate the source.
Most FDA recalls are voluntary, but since January 2011, the FDA now has the authority to require a recall through the Food Safety Modernization Act.
For a recall to be ordered or requested, FDA must identify products involved and have at least some evidence that there is a “reasonable probability that an article of food … will cause serious adverse health consequences or death to humans or animals.”
“Both FDA and state public health officials have collected product and environmental samples,” the FDA said in the statement. “Laboratory testing is under way.”
Rocky Ford cantaloupes, named for a region along the old Santa Fe Trail about 130 miles (200 kilometers) southeast of Denver, are prized for their above-average sugar content.
Dr. Chris Urbina, director of the Colorado Department of Public Health and Environment, commented on the investigation into the Listeria outbreak:
“People at high risk for listeria infection should not eat cantaloupe from the Rocky Ford growing region… The department expects additional test results later this week that may help identify the specific source of the cantaloupe linked to the multistate outbreak.”
According to officials, general recommendations for avoiding Listeria infection include heating deli meats and hot dogs to steaming hot, and avoiding soft cheeses. In the particular case of the Listeria outbreak affected states, they are cautioning residents to refrigerate cut melon as well as to discard any melon that has remained at room temperature for more than 4 hours.
A new study has found that inhaling a concentrated cloud of insulin through the nose two times per day appears to slow — and in some cases reverse — symptoms of memory loss in people with early signs of Alzheimer’s disease.
The study was run by researchers from the Veterans Administration’s Puget Sound Health Care System in Washington on 104 subjects and is considered very preliminary. However, the study findings suggests that a safe, simple and cheap measure that boosts flagging metabolism in key areas of the brain could hold off or possibly derail the progression of the devastating neurological disorder in its early stages.
The preliminary results were published online this week by the Archives of Neurology.
Inhaling a cloud of insulin two times per day appears to slow symptoms of memory loss in people with early signs of Alzheimer's disease
As a metabolic hormone, insulin is best known for its role in treating diabetes, a condition in which the hormone is either insufficiently produced or poorly used by the body’s organs.
But in recent years, several studies have found that people with diabetes and pre-diabetes are at high risk of developing Alzheimer‘s. The autopsies have shown that diabetics whose condition was tightly managed had fewer of the brain tangles and plaques that are the hallmark of disease.
Studies involving animals have suggested that insulin deficiency in the brain may be a key factor in the progression of Alzheimer‘s.
Researchers decided to test insulin on people without diabetes who had been diagnosed with mild to moderate Alzheimer’s or amnestic mild cognitive impairment, a disorder characterized by increased forgetfulness that often progresses to dementia.
Subjects were divided into three groups: 36 of them inhaled 20 mg of insulin twice a day for four months, 38 got 40 mg twice a day, and 30 were given a saline solution.
After two months of treatment, 20 mg of insulin group had improved performance on a memory test. The gains persisted after four months of treatment and were still evident two months after the insulin treatment stopped.
Participants who got 40 mg of insulin had no change in their memory abilities, while those who got the placebo saw a decline. The differences between those on insulin and those on the placebo were “small in absolute terms,” the authors wrote. But they were robust enough that by generally accepted research standards, they are unlikely to have been the result of chance.
Patients taking either dose of insulin were rated by their caregivers as holding steady in their overall social, mental and everyday functioning, while those on the sham medication were rated as having declined. And on physician-administered tests of cognitive function, patients taking insulin showed less decline than those on the placebo.
In a subset of subjects who underwent additional measurements, researchers found that there were fewer amyloid plaque deposits, protein tangles and other physiological hallmarks of Alzheimer’s in those whose memory improved most on the insulin treatment compared with those who had weak responses or were on the placebo.
But the persistence of insulin’s effect was a mixed picture. Two months after the insulin treatments stopped, caregivers of people in all three groups noted similar declines in their overall daily function.
About 5.4 million Americans are believed to have Alzheimer’s, according to the Alzheimer’s Association. Scientists acknowledge that while they can diagnose the disease earlier and offer medications to temporarily slow the progression of symptoms, they have been stymied in their search for ways to prevent, halt or reverse it.
“It will take a larger study involving more patients over a longer time to figure out whether nasally administered insulin merely slows the march of Alzheimer’s or thwarts it,” said Laurie Ryan, a neuropsychologist who directs clinical trials involving dementia at the National Institute on Aging, which funded the pilot study.
“In the meantime, intranasal insulin has two things going for it: Insulin is already in wide use at relatively low cost, and the nasal inhaler allows it to be delivered directly and safely to the brain. That minimizes the risk of the hormone affecting blood sugar levels elsewhere in the body, which could be dangerous to kidneys, eyes and blood vessels.
“A safe, easy delivery system — those are things we’d love to see for any kind of treatment for Alzheimer’s disease,” Laurie Ryan said.
The miraculous drug is based on colchicine, an extract from the autumn crocus (Colchicum autumnale), known also as meadow saffran
Potentially, all solid tumors could be vulnerable to drugs developed this way, meaning it could be used against all but blood cancers.
In some tests of the drug, half of tumors vanished completely after a single injection and the results will be presented at the British Science Festival this week.
The miraculous drug is based on colchicine, an extract from the autumn crocus (Colchicum autumnale), known also as meadow saffran, and is at an early stage of development, being so far tested only on mice.
But the University of Bradford researchers are optimistic about drug’s potential in humans.
Professor Laurence Patterson said:
“What we have designed is effectively a <<smart bomb>> that can be triggered directly at any solid tumour without appearing to harm healthy tissue.
“If all goes well, we would hope to see these drugs used as part of a combination of therapies to treat and manage cancer.”
Colchicine has long been known to have anti-cancer properties but has been considered too toxic for use in the human body.
To solve this issue, the specialists attached a chemical “tail” to the substance, deactivating it until it reaches the cancer.
Once colchicine reaches the target, the tail is cut off by an enzyme called MMP (Matrix metalloproteinase involved in cell proliferation), which is found in tumors.
Once the tail is removed, the drug is activated, which then attacks and breaks down the blood vessels supplying the tumors with oxygen and nutrients.
Cancerous tumors use the blood supply to spread around the body and it is hoped that the treatment, called ICT2588, will also combat this.
The first tests on humans could start in as little as 18 months.
If the treatment will be successful, the drug could be on the market in 6 to 7 years.
Happy Feet, the world’s most famous penguin, who was rescued in a costly mission that restored him to his ocean home, may have ended up as a predator’s lunch.
Happy Feet, the wandering emperor penguin had been nursed back to health after being found on Peka Peka Beach in New Zealand – 3,000 miles north of its native Antarctica – in a very serious condition, after eating sand he thought was snow.
A human surgeon helped the vets in removing sticks and stones from Happy Feet‘ stomach.
Happy Feet on Peka Peka Beach in New Zealand
The emperor penguin then had a GPS transmitter attached to him so his progress back into Antarctic waters could be tracked when he was released back into the ocean two weeks ago.
It appears the GPS transmitter attached to Happy Feet stopped working last Friday – about half way to his destination in the Southern Ocean.
Specialists said there are two possibilities: one, the device fell off and is sitting at the bottom of the ocean while Happy Feet continues safely on his journey or, the worst, they fear he could also be eaten in the jaws of a predator.
Emperor penguins have a number of predators including sharks, seals and killer whales.
In an early statement, Sirtrack, the company that attached the transmitter, told the New Zealand Herald that the lack of signal “leads to the conclusion that either the satellite transmitter has detached or an unknown event has prevented Happy Feet from resurfacing”.
A Sirtrack spokesman, Kevin Lay said there was “a chance” Happy Feet had been eaten, adding: “That’s what makes the world go round.”
Lay also said that the transmitter appeared to be in good working order up to the time it stopped sending data and the most likely explanation for the silence is that it had fallen off.
“The transmitter had been only glued on so that it would fall off in time.
“We hoped it would stay on for five or six months, but it appears in this case it’s only stayed on for two weeks.”
Lay added that it was possible that Happy Feet had been eaten, but he was doubtful.
“There are some species that will forage on emperor penguins but it’s not likely that it has happened to Happy Feet because of the area he was in,” he told New Zealand’s ONE News.
“We firmly believe that the transmitter has become detached.”
The spokesman said another possibility was that Happy Feet was underwater when the satellites that picked up the GPS signals were overhead.
“Maybe he’s just spending a lot of time under water because he’s found a good source of food,” said Kevin Lay.
Happy Feet underwent four surgeries at Wellington Zoo to remove sticks and stones from his stomach
Vets at the Wellington Zoo and experts who have been tracking the penguin’s progress all agreed that the next few days were critical.
Happy Feet was named after the 2006 animated feature about a tap-dancing emperor chick.
The penguin underwent four surgeries at Wellington Zoo to remove sticks and stones from his stomach and then spent two months in rehabilitation before being released into the ocean, well short of his habitat.
Happy Feet was placed on a tarpaulin slide running from the boat's ramp to be released in the sea
An international treaty prevents authorities from returning the penguin directly to Antarctica, so Happy Feet was released in an area where other juvenile emperor penguins like himself are at play at this time of the year.
When Happy Feet had finally been given a clean bill of health, he was placed in a specially-designed crate filled with ice and loaded onto the research vessel Tangaroa.
Sea conditions were too rough for Happy Feet to be released by hand, so he was placed on a tarpaulin slide running from the boat’s ramp.
Women who use painkillers such as ibuprofen during pregnancy are twice as likely to suffer a miscarriage, according to a University of Montreal study.
Specialists warn that tens of thousands of expectant mothers are taking the pills unaware of the dangers.
The major study, which was run by the researchers at University of Montreal, Canada, has found that women who took ibuprofen or similar painkillers just before they conceived until the 20th week of pregnancy were 2.4 times more at risk.
Although there are visible warnings on the drugs’ insert package saying they should not be used in pregnancy, as many as one in six expectant mothers still take them.
The Canadian study involved a group of painkillers known as Non-Steroidal Anti Inflammatory Drugs or NSAIDS, which include OTC’s (over-the-counter) ibuprofen and naproxen.
Aspirin (acetylsalicylic acid) is also in this category although it wasn’t included in the study, while paracetamol is deemed safe.
The Canadian researchers believe taking any number of the drugs can lead to the embryo not being properly implanted in the womb meaning a woman is far more likely to suffer miscarriage, which known as a spontaneous abortion.
Approximately one in eight pregnancies end in miscarriage and the majority happen in the first 12 weeks.
Often there is no obvious cause but older women and those who smoke, drink heavily or are obese are at far higher risk.
The study involved 47,050 women aged 15 to 45 and its results have been published in the Canadian Medical Association Journal.
The participants into the study were asked whether they had taken the painkillers at any time in the first 20 weeks of their pregnancy or two weeks before they became pregnant.
Despite the drug insert package warnings, about 17% of women had taken the drugs – nearly one in six.
Dr. Anick Bérard, researcher at the University of Montreal said:
“We consistently saw that the risk of having a spontaneous abortion was associated with gestational use of diclofenac, naproxen, celecoxib, ibuprofen and rofecoxib alone or in combination.
“Women who were exposed to any type and dosage of non-aspirin NSAID during early pregnancy were more likely to have a spontaneous abortion.”
But doctors pointed out the risks of a woman suffering a miscarriage due to painkillers were very small.
They also said the study did not take into account other possible causes such as smoking and obesity.
The most expensive house in the world is an 8.6 billion euro (over 12 billion dollars) residence, which has been built at the border of Switzerland and Italy.
It said that 200 kg of precious metals were used during construction of the most expensive residence on the planet.
The most expensive house in the world is located at the border of Switzerland and Italy
The building was designed by luxury designer Stuart Hughes, in collaboration with Exclusivhaus.
The 8.6 billion euro house has eight rooms and a huge living room of 725 square meters
The world’s most expensive house, which is located at the border of Switzerland and Italy, costs 8.6 billion euro because of the 200 kg of precious metals, gold and platinum, used to decorate the interiors. The impressive residence is situated on a plot of 2442 square meters, has eight rooms, a cellar of 242 square meters, a huge living room, which covers 725 square meters and four parking spaces, among others.
It said that 200 kg of precious metals were used during construction of the most expensive residence on the planet
Building of the most expensive house in the world took over five years. For security reasons, the world’s most expensive house owner was not named.
Beautytek claims to reshape bodies for both men and women
A non-invasive technique, Beautytek,claims to reshape, lift and tone over nine areas of the body.
Practitioners said Beautytek can lift breasts by up to five centimeters, flatten stomachs, lift buttocks and thighs, smooth out cellulite, reduce acne, scarring, wrinkles and stretchmarks.
The treatment seems to be pain free, without side effects. After twelve sessions one’s appearance is change and with one to two top up treatments each year, the results last a lifetime, it is said. Without annual treatment, the effects last only several months.
“Beautytek triggers the body’s natural chemicals to encourage anti-aging of the skin to take place.There is nothing artificial or chemical about the device which makes it an entirely drug-free treatment without the need for surgery.” Said Henning Buscher who helped develop Beautytek.
Beautytek combines ancient Chinese principles of acupressure (certain points of the body are stimulated to adjust energy flow) with modern technology.
This technique could balance the organiwsm by stimulating the lymphatic system blood circulation, hormonal release, and metabolism.
The practitioners said the human body has its own electro-magnetic field and they think fatigue, weight problems and skin complaints (spots, wrinkles) are caused by inefficient electrical flow.
A computer analyzes one’s electro-magnetic field and if the electrical current is slow, the computer stimulates certain acupressure – or energy – points with mild electrical pulses.This triggers movement of fluid between skin cells and “push out” fat from cells. The excess fat passes along the lymphatic drainage system towards the kidney and it is eliminated from the organism through urine. The blood circulation is increased on the stimulated areas and tone the muscles. Beautytek also triggers the endocrine system into releasing the correct amount of hormones. The combined effects boosts natural collagen production of skin cells. A session takes around 45 minutes and the need to urinate may occur during it.
Every adult can undergo a Beautytek treatment except pregnant women and people with pacemakers, said the practitioners. However, it is better to get medical exam and a consult from the GP before the treatment.
Dr Horst Frank, a dermatologist from Frankfurt, Germany, has monitorised 150 patients over a year in his clinic and the patients report their treatment was 90 per cent successful.
In the same time the dermatologists warn that there’s no proving that Beautytek works until double blind clinical trials have been completed.
“I’m not aware of any reason why people shouldn’t use the method, but unless there is reasonable data to prove that the claims work, I can’t endorse the treatment.” said Dr Neil Walker, a dermatologist at the Churchill Hospital in Oxford.
Iniatially Beautytek was designed as a device to treat pain in hospitals, then the technique was developed in Italy in 2000 for cosmetic purposes. Beautytek has been used in over 30 countries, including Germany, Switzerland, Sweden, Norway, Austria, US, Canada, China, UK.
People who ate more chocolate had lower incidents of cardiovascular disease and stroke compared to those who ate less, a study finds.
Eating chocolate could benefit the heart, possibly lowering heart disease by 37%.
The results coming from a meta-analysis were released online this week in the British Medical Journal.
Researchers from the United Kingdom and Colombia focused on 7 studies looking at the link between eating chocolate and a reduction in heart disease that included 114,009 people.
Eating chocolate could benefit the heart, possibly lowering heart disease by 37 percent
Of those 7 studies, 5 showed an association between higher levels of chocolate consumption and a lowered risk of cardiometabolic illness. The highest levels were linked with a 37% drop in cardiovascular disease and a 29% reduction in stroke, compared to the lowest levels.
There was no significant association seen between chocolate consumption and heart failure, and only one study drew a link between eating chocolate and a lowered risk of diabetes.
None of the studies, including the meta-analysis, were funded by a chocolate company or a related industry.
However, the study authors caution about eating chocolate with abandon. After all, they point out, chocolate isn’t exactly calorie-free. Although the participants in the studies ate a variety of chocolate products, including chocolate bars, drinks, nutritional supplements and desserts, all chocolate is not created equal, and eating too much of the stuff that’s filled with fat and sugar can put on pounds, possibly upping the risk of high blood pressure and diabetes — the very stuff that can lead to cardiovascular problems.
The study authors noted that among the studies there was no obvious dose-response relationship between chocolate and the risk of cardiometabolic disorders, so for now, everything in moderation, as they say.
And although the studies reviewed did control for a number of factors, including age, body mass index, physical activity, smoking and aspects of diet, there still may be other factors at work causing the heart benefits.
If chocolate is the root of these heart-healthy advantages, it may be due to its polyphenol content, anti-oxidants that could improve endothelial function (which may affect the risk of stroke and heart attack) as well as have a positive effect on blood pressure and insulin resistance.
More studies are needed, the authors wrote, to go beyond just an association and determine causation.
Adolf Hitler’s tea house, placed on the top of a Bavarian mountain, has become one of the most visited sites in Germany.
German Tourism authorities announced that over 300,000 people visited the tea house in a year. This is nearly 30,000 up on last year.
The tea house on the peak of the Kehlstein Mountain was built for Hitler as a 50th birthday gift by Nazi party secretary Martin Bormann in 1939.
Adolf Hitler’s tea house, placed on the top of a Bavarian mountain, has become one of the most visited sites in Germany
Hitler’s Berghof home on the mountain was destroyed by the Allies in bombing raids and after WW2, but the tea house survived and became a tourism attraction in peacetime.
According to officials, most visitors to the mountain are Americans followed by Britons; combined they make up 85% of the people who came to see where Hitler ate cream cakes with his mistress Eva Braun and snoozed in chintz chairs as the world war he started raged.
Germans make up just a small proportion of visitors to the “Eagle’s Nest” tea house.
For 20 euros (about $30) , visitors to the house 6,000 feet up are rewarded with spectacular views and can get refreshments from the privately run restaurant, including roast pork with dumplings and cabbage, salads and sandwiches, that operates in summer months inside it.
There is even a gift shop.
Visitors access the tea house on a bus via a serpent-like mountain road called the Kehlsteinstrabe and enter a golden brass lift built into the mountain side, itself accessed via a tunnel through the granite.
The Kehlsteinhaus (Eagle’s Nest in English) is built in a chalet-style taking 13 months to construct.
The tea house was finished in the summer of 1938 before it was presented to Hitler a year later, but he only made a few visits to the chalet partly due to his fear of heights.
After the war, the retreat place was used by the Allies as a military command post until 1960 when it was handed back to the State of Bavaria.
The new tourist attraction is 1834m above sea level and is perched on a rock wall having cost 30 million Reichsmarks to build (about $180 million today).
Countless overweight men and women have starved themselves for a short period until they quickly lost the fight for weight loss.
The truth is that you can shed some weight simply as a result of eating less calories. However, very many people will explain to you that is a challenge to do as well as maintain. There will most certainly be too many difficult behavior changes regarding eating considerably less, or even half-starving your self. Positive along with healthy lifestyle and eating improvements will be much simpler to accomplish with a different approach. The basic policy is to do a reduced amount over time and little by little make the desired shift.
Weight Loss Target
Excessive caloric intake causes weight gain in nearly everyone. A small minority cannot put on pounds irrespective of how much they eat. Nevertheless you have to be aware that your body needs calories to work at a good level. You can get by with a bare minumum daily caloric intake, but the likelihood is very good that you would feel exhausted, sluggish, hungry and miserable. Consequently the initial step would be to begin decreasing foods that are not helping your weight difficulty. You’ll find it much easier to lessen, initially, than attempt to completely eliminate them.
Naturally you should make a parallel effort to begin with eating healthier foods on a daily basis to achieve and maintain weight loss.
Yet again, you do not need to make a significant change here, or even a total lifestyle makeover. For people who have tried implementing total change and were unsuccessful, then this may be an agreeable strategy for you. Effortlessly begin by making modest changes, and then keeping them on a daily basis for a period of time. As soon as you feel comfortable with that magnitude of change, then you can make another modification in your daily diet. On top of that, you may consider introducing some kind of physical exercise to your weekly routine.
It becomes very beneficial if you take a look at the quality of calories and fats you take in each day. Empty calories are most likely the worst, and a good illustration of that are all kinds of sugar. Then, one needs fat in your diet, but it is the sort of fat that makes a significant difference. Ready-made foods and fast foods are great examples of the incorrect kinds of fats for you. When you notice that you are eating these fattening foods far too much, then slowly begin reducing them. The key point here is to make some form of positive change that will assist you.
Weight Loss - Eat Healthy Vegetables
It’s essential to make these small changes an integral part of your new behaviors and routines. This is going to of course take time, but that is the trade-off any time you make smaller modifications. On the other hand, this method will certainly work for some people who cannot make drastic changes. Just don’t forget that you need to keep striving forward and cutting out increasingly more fattening foods. You certainly will, at some point, make a reasonable change so you begin to see greater success. There isn’t anything more inspiring than results in any endeavor. This works for weight loss too.
The 9/11 tragedy from World Trade Centre has taken a heavy toll on the health of those who tried to rescue people from the burning buildings, those who took part in the clean-up, and those who lived near the site, research shows.
The rescuers who endangered their lives trying to save people have paid a long-term price: a 19% higher risk of cancer as a result of exposure to toxic fumes, according to a study published in a special The Lancet series to mark the 10th anniversary of the atrocity.
Other research in the series reveals the scale of mental and physical damage suffered by rescuers and witnesses.
Dr. David Prezant, chief medical officer of New York City fire department, and colleagues studied the firefighters, together with others from the Albert Einstein College of Medicine at Yeshiva University, and Montefiore Medical Centre, New York.
The rescuers at 9/11 WTC are at 19% higher risk of cancer as a result of exposure to toxic fumes, according to a study published in a special The Lancet series to mark the 10th anniversary of the atrocity.
“In the years following the disaster, the firefighters began to ask about cancer. The World Trade Centre fire was like no other they had encountered,” said Dr. Prezant.
“Firefighters are not environmental scientists, but they have the common sense test,” Dr. Prezant told the Guardian.
“What they said after coming out of those buildings after participating in the rescue and recovery effort was not just that the magnitude was great; they felt they were affected in a different way.
“Most firefighters have learned there are different smells to fires. They repeatedly said to us that this area smelled different. They said this was unlike any other firefight we’ve had before.
“We have a unique group of people. On 9/11 the firefighters ran into these towers, many of them after the south tower had collapsed, with nothing in their minds except saving everyone who was in there. We concentrate on the nearly 3,000 people who died there and the 343 firefighters who died that day, as we should, but we should never forget that 20,000 to 30,000 people were evacuated from that building because of the heroic efforts of these responders.
“In subsequent years they did voice concern, asking: <<What’s going to happen to me?>>. From day one we have said we will find out and we will provide you with the services necessary to help you.”
“One of the strengths of the study is that every firefighter who was there on September11, 2001 has had many health checks since,” Dr. Prezant added.
The researchers’ efforts to avoid an over-screening bias have brought the percentage estimates down. Originally they found an increase of 32%.
The cancers are various, but the most common were those of the skin, prostate, thyroid and non-Hodgkin’s lymphoma. The authors say a link between exposure to the pollutants given off by the World Trade Centre and cancer is biologically plausible because “some contaminants in the WTC dust, such as polycyclic aromatic hydrocarbons, polychlorinated biphenyls, and dioxins, are known carcinogens.”
Dr. James Melius of the New York State Labourers’ health fund calls for inclusion of cancer in the government-funded medical programme for firefighters.
“Waiting to do so until definitive cancer studies have been completed (probably many years from now) would be unfair and would pose a hardship for workers who willingly risked their health by responding without hesitation to the WTC crisis,” Dr. Melius said.
So far, rescue workers and civilians exposed to the dust have lower death rates than other comparable groups in New York, according to another study. But researchers say that is not surprising, because most were employed or volunteers – both groups that generally have better health – and the illnesses they might succumb to as a result of 9/11 generally do not cause death within 10 years.
Nonetheless, the more than 50,000 rescue and recovery workers who went to help at the WTC are suffering from high levels of mental and physical illness, says a third paper.
“Our findings show a substantial burden of persistent physical and mental disorders in rescue and recovery workers who rushed to the site of the WTC and laboured there for weeks and months 10 years ago. Many of these individuals now suffer from multiple health problems,” write Dr. Juan Wisnivesky and colleagues from the Mount Sinai School of Medicine in New York.
28% of the rescue and recovery workers have suffered depression at some time since 9/11; 32% have experienced post-traumatic stress disorder, and 21% panic disorder. Police officers have lower rates – 7%, 9% and 8% respectively – perhaps because of previous stressful experiences, the sort of people who are recruited, or under-reporting for fear of job-related repercussions.
Many of the 27,000 workers, including police officers, firefighters, construction workers, and municipal workers, whose health has been monitored since 9/11 have breathing-related problems. 42% have respiratory problems.
“Inhalation of toxic, highly alkaline dust is probably the cause of upper and lower respiratory injury in rescue and recovery workers,” says the report.
Over nine years, 28% have had asthma, 42% sinusitis and 39% gastro-oesphageal reflux disease.
Matthew Mauer of the New York State department of health writes in a further commentary: “As we mark the 10th anniversary of 9/11, reports of persistent health effects are a sobering reminder that the disaster has had far-reaching effects. One cannot help but wonder what will be reported when we mark the 20th anniversary of this tragedy.”
A high protein, but low carbohydrate diet has long been hailed as a successful weight-loss method, but a new study of the McMaster University has found that protein-rich dairy foods can help aid this further.
Canadian researchers from McMaster University in Hamilton, Ontario, Canada, found that those consuming higher-protein, high-dairy diets experienced more abdominal fat loss and the greatest amount of whole-body fat.
The Canadian study monitored three groups of obese and overweight pre-menopausal women – each group undertaking either a low, medium or high amount of dairy foods along with high or low amounts of protein and carbohydrates.
The women then took part in aerobic exercise 5 times a week and circuit weightlifting 2 days a week over a 4 months period.
The study findings showed that the women on higher-protein, high dairy group lost the greatest amount of whole-body fat and belly fat.
The McMaster University study findings showed that the women on higher-protein, high dairy group lost the greatest amount of whole-body fat and belly fat.
The lead author of the study, Andrea Josse, from the Department of Kinesiology at McMaster University in Hamilton, Ontario, said:
“100 per cent of the weight loss in the higher-protein, high-dairy group was fat.
“And the participants gained muscle mass, which is a major change in body composition.
“The preservation or even gain of muscle is very important for maintaining metabolic rate and preventing weight regain, which can be a major problem for many seeking to lose weight.”
The Canadian study will be published in the Journal of Nutrition in September.
The 46th edition of the MDA Telethon, which will be held in Las Vegas on September 4, is the first show in the entire telethon history without Jerry Lewis’ hosting.
According to organizers, this fall MDA Labor Day Telethon will air in every time zone from 6 p.m. to midnight on Sunday, September 4, broadcasting from the South Point Hotel in Las Vegas.
In 2011, MDA Labor Day Telethon for the first time without Jerry Lewis
Jerry Lewis, 85, has been MDA’s national chairman since the early 1950s and has hosted the MDA Labor Day Telethon since 1966.
Last May, Jerry Lewis made the announcement that he was retiring as host of the telethon, but added that he would make a final appearance on 2011 show and planned on continuing to serve as Muscular Dystrophy Association’s national chairman.
At the beginning of August, came the surprising news that Jerry Lewis was no longer the MDA’s national chairman and would not take part in 2011 MDA Telethon.
At that time, R. Rodney Howell, MDA Chairman of the Board said in a statement that Lewis “will not be appearing on the telethon” and “we will not be replacing him as MDA national chairman.”
Rodney Howell added that Lewis “is a world-class humanitarian and we’re forever grateful to him for his more than half century of generous service to MDA.”
Though the organizers have not announced a replacement for Jerry Lewis, they promise a full of entertainment program for the 2011 MDA Labor Day Telethon show, as it was posted on association’s website:
“The 46th annual MDA Labor Day Telethon is getting ready to squeeze 21½ hours of entertainment, awareness-building and fundraising into six prime-time hours on Sunday night, Sept. 4.
The shorter show, which is expected to draw more viewers in its prime-time slot, will be fast-paced and jam-packed with top-notch entertainment.
In addition to the shorter national broadcast, each hour of the local Telethon will feature two local segments of seven and eight minutes each.
Top talent and tweets
The prime-time slot already is attracting new talent, such as country music superstars Darius Rucker, Lady Antebellum and Martina McBride.
In addition, talented co-hosts Nancy O’Dell, Nigel Lythgoe, Jann Carl and Alison Sweeney will keep things hopping, joined by MDA National Goodwill Ambassador Abbey Umali, 12.
MDA’s social media will add a new dimension to the show with “tweets” and online posts from behind the scenes.
Watch for spontaneous video interviews with Telethon families and celebrities, and follow all the backstage Telethon action on MDA’s Facebook page and Twitter account. These extras will be posted on the MDA website.
Four remarkable young people living with neuromuscular disease will be the subjects of video profiles.
MDA’s own version of “American Idol” — Clear Channel’s Get Discovered! contest — again will highlight new musical talent.
New prime-time schedule
Approximately 160 “Love Network” stations will carry the show from coast to coast, and it will be seen around the world via mda.org.
In the 46 years since it began, MDA’s signature event has meant help and hope for those affected by neuromuscular disease — and that’s one thing that will never change.”
The MDA Telethon is an American television institution and is seen each Labor Day weekend by more than 40 million viewers, having an audience comparable to that of the Academy Awards and greater than that of American Idol, Dancing with the Stars, the Emmys and the Golden Globes, according to MDA website.
A new study’s findings showed that the best way to burn belly fat is through aerobic exercise instead of weights lifting.
Researchers from Duke University of North Carolina, US, have monitored people who did aerobics for 8 months and compared them to those who did just weights lifting.
The group of participants into study lost almost 20 times as much fat around their stomachs.
The aerobics group lost around 2.5 square inches (about 16 sq cm) of belly fat, and a group that combined both aerobic and weights lifting lost only 1.5 square inches (less than 10 sq cm).
The best way to burn belly fat is through aerobic exercise instead of weights lifting
Cris Slentz, from Duke University, who undertook the study, said:
“Resistance training is great for improving strength and increasing lean body mass.
“But aerobic exercise is better for losing belly fat because it burns more calories.”
Other study’s findings showed that those who combined weights lifting and aerobics didn’t see any further health benefits than those who only did aerobic, in terms of insulin resistance and liver fat, as Live Science reported.
Duke University researchers therefore concluded that aerobic exercise alone is more beneficial for obese and overweight individuals.
According to specialists, “belly fat” is defined as visceral fat, which is found deep in the stomach that surrounds the internal organs, as opposed to subcutaneous fat that is found underneath the skin.
Visceral fat is more threatening to health, as it lies closer to the organs and is associated with diabetes, heart disease and certain types of cancer.
Duke University researchers studied 196 overweight, sedentary adults between 18 and 70 ages, who were divided into three exercise groups – aerobics, weights lifting and combined.
Cris Slentz added:
“When it comes to increased health risks, where fat is deposited in the body is more important than how much fat you have.
“What really counts is how much exercise you do, how many miles you walk and how many calories you burn.
“If you choose to walk at a lower aerobic intensity, it will simply take longer to burn the same amount of unhealthy fat.”
The study will be published in the American Journal of Physiology Endocrinology and Metabolism.
On Monday, August 29, a knife attack, with eight children stabbed, occurred at a daycare center for migrants in suburban Minhang district of Shanghai.
The children stabbed at a daycare center in eastern China were taken to the hospital
The children were taken to the hospital for medical care. One was relatively severely injured and four had mild wounds, but none of the children suffered life-threatening injuries, Xinhua News Agency reported.
The kids were slashed by a woman who works at that daycare center, possibly a teacher. She was arrested and the police began the investigation, said Zhuang Liqiang of the Shanghai Public Security Bureau. He added no further details.
Apparentely the woman had a “psychotic episode”, said Xinhua News Agency and local reports. “The teacher is bad” said the mother of a child who was attacked.
Lots of adults and children died or were hurt in recent years in Chinese schools, nurseries and other public places. This led to an increasing security in schools and nurseries.
The Minhang district of Shanghai has a lot of migrant workers. The children of migrant workers are not usually qualified to attend city public schools and their parents cannot afford to pay the fees for private facilities. There are ten millions of people who work in the cities, far from their rural homes. Their children remain unsupervised or in grandparents care.
Because of safety concerns there were local moves that closed the informal schools and nurseries. Without these facilities to cater for migrant families, the migrant persons have a bigger problem with children care.
Shanghai’s Dragon TV showed children’s clothing at the hospital covered with blood. Doctors said they had to cut off the clothes quickly to treat the children’s injuries.
Snacking regularly on biscuits or cakes can significantly increase women’s chances of developing womb cancer, a British study shows.
Women who eat biscuits or cakes two to three times a week were 33% more likely to suffer womb cancer than those who rarely served such sweets.
Among those women indulging more than three times a week, the risk of developing womb tumors is increased with 42%.
However, their overall chances were still low as the odds of the average woman in the study developing uterus cancer during 18-plus years of the research were just over 1%.
The British researchers described the size of the effect as “modest” but said it warranted further investigation.
British cancer experts emphasized that it is too early to draw any firm conclusions.
Biscuits and cakes increase womb cancer risk by 42 percent
The scientists from Stockholm’s Karolinska Institute explained the link between increased sugar levels and womb cancer.
The researchers studied data from thousands of women who, between 1987 and 1990, had answered dozens of questions on diet, lifestyle, weight and general health.
In 1997, those still alive answered an even more extensive battery of questions on their eating habits.
In 2008, the researchers matched up the women’s answers with their medical records, specifically looking for diagnosis of endometrial cancer – the most common form of womb cancer. They found 729 cases out of the 61,226 women studied.
There was little or no increase in risk from eating certain high-sugar items such as sweets, soft drinks, jam or marmalade.
But women who snacked frequently on cakes, buns or biscuits were up to 42% more likely to get uterus cancer than those who had them two times per month or less.
It is not clear why some sweets were linked to the womb cancer developing but others were not.
The study looked at how often volunteers ate such sweets but not specifically how much. However, those exceeding a total intake of more than 35 grams of sugar a day – equivalent to about seven teaspoons – faced a 36% increase in tumor risk.
The Swedish scientists from Stockholm’s Karolinska Institute said there are two mechanisms that high levels of sugar could raise the risk of the endometrial cancer. One is that increased quantity of sugar makes the body release more insulin, which has been shown to stimulate the growth of endometrial stromal cells, the lining of the womb
Another mechanism is that high levels of insulin may also increase levels of free estrogens through decreasing concentrations of circulating sex hormone–binding globulin, which has been shown to trigger the uncontrolled growth of cells, a key characteristic of cancer.
The Swedish study findings were published in the journal Cancer Epidemiology, Biomarkers & Prevention.
Yinka Ebo, senior health information manager at Cancer Research UK, said keeping a healthy weight and staying physically active were the best ways to reduce womb cancer risk.
She added: “This study shows eating lots of sugar and certain sugary foods may increase the risk of womb cancer, but we would need to see these results repeated in other large studies like this before we can draw any firm conclusions.”
Endometrial cancer affects around 6,400 women a year in the UK and kills an estimated 1,000 annually.
Risk goes up with age, weight and with having a mother who had the disease. However, having children appears to lower the risk.
Several packs of Nurofen Plus were found to contain Seroquel XL, a powerful anti-psychotic drug used to treat schizophrenia, on Thursday.
Friday, after a safety alert was issued, pharmacists have been told to check each package of Nurofen Plus to look for anti-psychotic drugs after sabotaged packs were found in Boots stores across London the day before.
Nurofen Plus packages containing Seroquel XL blisters have been found in Boots stores in Victoria, Beckenham and Bromley.
Several packs of Nurofen Plus were found to contain Seroquel XL in pharmacies accross London
It is speculated that militant activists for animal protection carried out the sabotage operation with the intention of damaging Nurofen Plus’s producer, Reckitt Benckiser.
The pharmaceutical company may have been targeted because it tests some products on animals, although not Nurofen Plus.
Reckitt Benckiser said Friday that it didn’t know where the drugs had been switched.
[googlead tip=”patrat_mediu” aliniat=”dreapa”]
Nurofen Plus packages containing Seroquel XL blisters have been found in Boots stores in Victoria, Beckenham and Bromley.
Boots’ spokeswoman told the Evening Standard:
“We are working closely with the MHRA to aid investigations and we have communicated with our stores and asked our pharmacists to be extra vigilant by checking the Nurofen Plus packet before selling it.”
The “sabotaged” Nurofen Plus packs – containing a total of 500,000 tablets – have been sent to pharmacies across the UK.
It is suspected that blister strips containing the tablets have been changed while in a wholesalers’ warehouse.
On Thursday, 3 tampered Nurofen Plus packs were discovered in south London, and an immediate investigation is under way to identify whether a group or an activist acting alone was behind the action of changing blisters.
Siân Boisseau, director of Virgo Health, the PR company which represents Nurofen, told the Mail:
“There has been a suggestion that the packets were deliberately put in the wrong boxes.
It was not discovered until the packets arrived in store. It was not in the manufacturing process or supply chain. It is not a mix-up and is still being investigated.”
A Virgo Health spokesman added police were not involved so far but could be in the future.
Patients who accidentally take the antipsychotic Seroquel XL may experience sleepiness and are advised not to operate any tools or machinery until they know how the tablets have affected them.
AstraZeneca, producer of Seroquel, said those who had mistakenly taken the drug should contact their GP and bring the blisters back to the pharmacy where they bought it.
Seroquel XL side effects include dizziness, headache and sleepiness, which affect more than one in ten users.
[googlead tip=”lista_mare” aliniat=”stanga”]Nurofen Plus and Seroquel XL are packaged differently – the blisters containing large capsules of Seroquel XL 50mg tablets have gold and black packaging while the Nurofen Plus pills are smaller and have silver and black packaging.
The Medicines and Healthcare Products Regulatory Agency (MHRA) has asked pharmacists to check 32-tablet packs of Nurofen Plus, which is sold only in pharmacies.
There are three batches of Nurofen Plus which were affected by the alert.
They are: batch number 13JJ, expiry date 03/2014, licence number 00327/0082; 57JJ, 05/2014, 00063/0376, and 49JJ, 05/2014, 00063/0376.
Each batch contains 4,000 -7,500 packages, amounting to around 500,000 tablets.
It said that not all packs are affected.
Ian Holloway, from the MHRA’s defective medicines report centre, said:
“People should check to see if they have any affected packets of Nurofen Plus. If you do, return them to the pharmacy where you bought them from.”
Reckitt Benckiser said “serious investigations” were under way to establish how and who switched the blisters, especially as Seroquel XL is manufactured by a different pharmaceutical company.
Reckitt Benckiser added:
“After careful review of the manufacturing system, manufacturing errors by the makers of Nurofen Plus or Seroquel XL are not thought to be part of the cause at this stage.
We are taking this matter very seriously and are working closely with the regulatory authority, the MHRA, and pharmacies. The MHRA are investigating the issue, and have considerable law enforcement powers.
Nurofen Plus is not available for self-selection from the shop floor – and therefore pharmacists are able to check packs and greatly reduce the likelihood of affected packs being sold.”
Dr. Aomesh Bhatt, medical director for Nurofen Plus, said:
“We are taking this matter extremely seriously and we are working closely with the MHRA.
Additionally, we are in the process of working to ensure the Nurofen Plus packs are double-checked by pharmacy staff before they are handed to customers.
We encourage consumers of Nurofen Plus to be vigilant and, while it is very unlikely, should they find they have a suspect pack or if they have any other concerns, we advise them to speak to the pharmacist where they purchased the product.”
Dr. Bhatt added that Nurofen Plus had a “firm policy” of not testing on animals.
Seattle Genetics, Inc. (Nasdaq: SGEN) announced that the U.S. Food and Drug Administration (FDA) has granted accelerated approval of Adcetris (brentuximab vedotin) for two indications.
1. the treatment of patients with Hodgkin lymphoma after failure of autologous stem cell transplant (ASCT) or after failure of at least two prior multi-agent chemotherapy regimens in patients who are not ASCT candidates, and
2. the treatment of patients with systemic anaplastic large cell lymphoma (ALCL) after failure of at least one prior multi-agent chemotherapy regimen.
[googlead tip=”lista_mare” aliniat=”stanga”]The indications for Adcetris are based on response rate. There are no data available demonstrating improvement in patient-reported outcomes or survival with Adcetris.
Adcetris is the first drug approved by the FDA for Hodgkin lymphoma in more than 30 years, and provides a new therapeutic alternative for Hodgkin lymphoma and systemic ALCL in these settings.
Adcetris will be available to patients this week
Seattle Genetics expects to make Adcetris available to patients this week.
Adcetris is an antibody-drug conjugate (ADC) directed to CD30.
“Bringing a new product to the market is a significant milestone for Seattle Genetics in fulfilling its mission to improve the lives of people with cancer,” said Clay B. Siegall, Ph.D., President and Chief Executive Officer of Seattle Genetics.[googlead tip=”vertical_mediu” aliniat=”dreapta”]
“The approval of Adcetris is a result of more than a decade of research and development by talented scientists and physicians. The company has deep appreciation for the hundreds of patients who participated in Adcetris trials, and the passion and determination of the clinicians at sites around the world in investigating this first in a new class of targeted anticancer agents.We are committed to continued clinical investigation of Adcetris through a broad developmentprogram for CD30-positive malignancies, including confirmatory trials in front-line Hodgkin and T-cell lymphomas that we have planned in consultation with the FDA.”
“The marked single agent activity seen with Adcetris, including a high durable complete remission rate, offers an opportunity to improve the treatment paradigm of patients for whom the treatment is indicated,” said Owen A. O’Connor, M.D., Ph.D., Professor, and Director, Division of Hematology and Medical Oncology at NYU Cancer Institute.
“This approval represents a major advancement in the care of these patients.”
Seattle Genetics also announced that it has established a patient assistance program named SeaGenSecure™ that offers patients and providers access to Adcetris reimbursement support, benefit investigations and patient assistance programs.
Seattle Genetics is jointly developing Adcetris with Millennium: The Takeda Oncology Company.
Under the terms of the collaboration agreement, Seattle Genetics has U.S. and Canadian commercialization rights and the Takeda Group has rights to commercialize Adcetris in the rest of the world. Seattle Genetics and the Takeda Group are funding joint development costs for Adcetris on a 50:50 basis, except in Japan, where the Takeda Group will be solely responsible for development costs.
People should be aware of early-onset dementia, learn what its symptoms are and how important is the early diagnosis.
Pat Summitt, 59, Tennessee women’s basketball coach has been recently diagnosed with early-onset dementia (Alzheimer’s type) when she visited the Mayo Clinic in Rochester, Minnesota.
[googlead tip=”patrat_mediu” aliniat=”stanga”]Last May, Mayo Clinic doctors performed a spinal tap and other tests that eventually produced the diagnosis of early-onset dementia.
In a statement released by the university on Tuesday, Pat Summitt said:
“I plan to continue to be your coach. Obviously, I realize I may have some limitations with this condition since there will be some good days and some bad days.”
“But I have been honest and shared my health concerns with you and now we will move on with the business involved. I hope that you will respect my privacy regarding this matter.”
Pat Summitt initially chalked up her memory problems to side effects from medicine she was taking to treat rheumatoid arthritis.
Pat Summitt talked about her early-onset dementia diagnosis.
Early-onset dementia is a term used for progressive dementia that begins before age 65, so, to be aware of its symptoms and visiting doctor for an early diagnosis are crucial.
[googlead tip=”vertical_mare” aliniat=”dreapta”] Linda Johnson, director of programs for Alzheimer’s Tennessee Inc. has some hope to offer to the people who have been diagnosed with early-onset dementia and call her office for help and : better treatments, education and support.
Over the past fifteen years, medications have improved for people diagnosed with “early-onset Alzheimer’s,” or “early-onset dementia”, a term used for progressive dementia that begins before age 65.
Most people diagnosed with early-onset dementia are in their 40s and 50s, though some are in their 30s. It accounts for only 5% to 10% of all Alzheimer’s disease cases.
[googlead tip=”lista_medie” aliniat=”stanga”]
Let’s see some of the early-onset dementia symptoms.
Early on, people may have difficulty with language, mixing up words. Later, they may fail to recognize something they should: a favorite restaurant, an article of clothing. They may start to have difficulty performing complex tasks, such as bookkeeping.
“Many times, it’s the co-workers of people with early-onset dementia who notice something is wrong, because most people are taxed with more complex tasks at work than at home,” Linda Johnson said.
“It’s very important to get a diagnosis as soon as possible,” she said, to rule out other things that sometimes cause dementia — vascular problems, for example, some blood clots and tumors, iron deficiency.
Starting medications, which can slow memory loss and other symptoms, ”EARLY is key”, Linda Johnson said.
“It can slow down the progression for years, in certain individuals, though there is no cure,” Johnson said,
But then, there’s the maxim Johnson heard from a trainer: “If you’ve seen one Alzheimer’s case, you’ve seen one Alzheimer’s case.”
She knows a person who lived with Alzheimer’s for 25 years, another who had only 18 months. 10 years seems to be average.
About 50% of early-onset dementia cases are linked to the mutation of certain genes, which means people can have a hereditary disposition to the disease. The other 50% of cases are similar to later-onset Alzheimer’s, and it’s not clear why they begin earlier in life.
A new University of California Davis study has found that happiness and well-being in adolescents report less involvement in crime and drug use than other youth.[googlead tip=”patrat_mic” aliniat=”dreapta”]
[googlead tip=”lista_mica” aliniat=”stanga”]About 29% of the students surveyed reported having committed at least one criminal offence, and 18% claimed they had used at least one illegal drug.
The researchers then correlated these reports with students’ self-assessments of emotional well-being and found that those who said they were happier were less likely to commit crimes or use drugs.
Happiness and well-being in adolescents report less involvement in crime and drug use than other youth.
[googlead tip=”vertical_mare” aliniat=”stanga”] “Our results suggest that the emphasis placed on happiness and well-being by positive psychologists and others is warranted,” said co-author Bill McCarthy, a UC Davis sociology professor.
The researchers also found that youth with even minor depression were much more likely to be involved in criminal activity or drug use. And while most of teenagers have periods of happiness and depression, “it’s when negative periods begin to outnumber the more positive ones that trouble can start,” the UC Davis researchers said.
“In addition to their other benefits, programs and policies that increase childhood and adolescent happiness may have a notable effect on deterring non violent crime and drug use,” said Prof. Bill McCarthy.
Prof. Bill McCarthy and Teresa Casey, a postdoctoral researcher at UC Davis argued that positive emotions also have a role.
The UC Davis team theorized that the benefits of generally happiness – such as maintaining strong bonds with others, feeling good about oneself, and gaining good social skills – can help teenagers make good decisions.
“We hypothesize that the benefits of happiness – from strong bonds with others, a positive self-image and the development of socially valued cognitive and behavioral skills – reinforce a decision-making approach that is informed by positive emotions,” they wrote in their study.
Their research finds that happier adolescents were less likely to report involvement in crime or drug use. Adolescents with minor, or nonclinical, depression had significantly higher odds of engaging in such activities.
The study was to be presented Monday at the Annual Meeting of the American Sociological Association in Las Vegas.
Since the study has not yet been published in a peer-reviewed journal, the findings should be viewed as preliminary.
According to a University of Michigan Health System statement posted on its website on August 22, the new stem cell lines developed from the skin of adults living with bipolar disorder are providing researchers at the University of Michigan Health System an unprecedented opportunity to delve into the genetic and biological underpinnings of the devastating mood disorder.
Scientists will be able to link new findings – such as how gene expression is affected by different medications – to extensive clinical and demographic data from the cell donors, who are also participants in an ongoing long-term study of hundreds of individuals with bipolar disorder.
The induced pluripotent stem cells could offer new hope for unlocking the secrets of bipolar disorder.
The new research comes as the Heinz C. Prechter Bipolar Research Fund, based at the University of Michigan Depression Center, prepares to mark the 10th anniversary of its establishment by Waltraud “Wally” Prechter following the July 2001 death of her husband, Heinz. Before he took his life, few people knew that the well-known automotive entrepreneur wrestled with bipolar disorder.
“Currently the best treatments for bipolar disorder are only effective for 30 percent to 50 percent of patients,” said Melvin McInnis, M.D., the Thomas B and Nancy Upjohn Woodworth Professor of Bipolar Disorder and Depression at the University of Michigan Medical School and associate director at the University of Michigan Depression Center.
“New discoveries have been limited, in part due to the lack of access to tissue and cells from individuals with bipolar disorder. But that is now changing because of the Prechter research program and advances in stem cell research.”
The new stem cell lines – among the first to be created by the A. Alfred Taubman Medical Research Institute Consortium for Stem Cell Therapies – were made from fibroblasts from skin samples donated by adult research volunteers both with and without bipolar disorder.[googlead tip=”patrat_mic” aliniat=”dreapta”]
In the lab, scientists can coax these skin cells into behaving like embryonic stem cells. Known as induced pluripotent stem cells, or iPSC, these, in turn, can be manipulated to develop into different types of body cells, including brain cells.
“We will be able to see if there are differences in how the neurons of a person with bipolar disorder make connections, determine how they respond to different medications and explore potential deficiencies in signaling pathways,” explained Sue O’Shea, Ph.D., a professor of cell and developmental biology at the Medical School who leads the stem cell lab with Gary Smith, Ph.D, professor of obstetrics and gynecology.
“So far, five lines have been created. The goal, is to develop 30 cell lines – 20 from people with bipolar disorder and 10 control subjects. Creating each line is a painstaking and expensive process.”
“We often think of stems cells being used in therapies to treat disease, but this is a great example of stem cells’ usefulness for studying the mechanisms of disease.”
“The iPS cells renew themselves, so they’re an unlimited source of material and offer hope to individuals with bipolar disorder.”
Still, the researchers caution, new treatments spurred by this work could be a decade or more away.
Bipolar disorder, formerly known as manic depression, affects 5.7 million adults in the United States. It is caused by chemical imbalances in the brain and marked by significant changes in mood, thoughts, energy and behavior.
Heinz Prechter, the well known automotive entrepreneur wrestled with bipolar disorder.
[googlead tip=”lista_medie” aliniat=”dreapta”]Because bipolar disorder runs in families, research at University of Michigan (U-M) has focused on studying disease genes. There is no single gene that “causes” someone to become bipolar, but the disease has its roots in genetic vulnerabilities.
The Prechter Bipolar Genetic Repository already houses more than 1,500 genetic samples from people with bipolar disorder and healthy controls from studies at U-M along with collaborating sites: Johns Hopkins, Stanford, Cornell and Penn State. It is the first independently funded bipolar genetics repository in the nation. In addition to sharing the knowledge between the different universities, confidential, coded DNA repository samples and clinical information will be made available to scientists worldwide to accelerate and share clinical breakthroughs in evaluating and treating bipolar disorder.
The Prechter longitudinal study has already collected more than 5 years’ worth of data.
“I’m really proud that over the last 10 years my husband’s legacy has grown to include the strides we’re making to understand bipolar disorder and find new treatments,” Wally Prechter says.
“Bipolar is like any other illness – cancer, diabetes, heart disease – and deserves the same urgency.”
“That lack of effective treatment is a big reason for the high risk of suicide or suicide attempts among people with bipolar disorder. Anywhere from 5% to 15% of bipolar patients will attempt or commit suicide sometime in their lives,” said McInnis.
“Depression caused by Heinz Prechter’s bipolar disorder affected his whole being,” said Wally Prechter.
“He was extremely exuberant and happy, and very, very optimistic, to the point that I thought, ‘Wow, I’ve never met anyone like that.’ But when he was depressed it was to the point that he would stay home and just sit in a chair and look out at the river,” she said.
The memory of how her brilliant husband was reduced to such a low, unable to tell anyone what he was going through, is part of what continues to drive her today.
U-M Health System CEO and Executive Vice President for Medical Affairs Ora Hirsch Pescovitz, M.D., points to the research as a great example of the strides that can be made when public institutions and private donors collaborate on research that benefits the public.
“The Prechter research shows how we continue to fuel innovation through exciting collaborations that highlight our commitment to bench-to-bedside medical advances,” Pescovitz said.
“We are very fortunate to have Wally and her family as part of our Michigan family.”
Privacy & Cookies Policy
Necessary cookies are absolutely essential for the website to function properly. This category only includes cookies that ensures basic functionalities and security features of the website. These cookies do not store any personal information.
Any cookies that may not be particularly necessary for the website to function and is used specifically to collect user personal data via analytics, ads, other embedded contents are termed as non-necessary cookies. It is mandatory to procure user consent prior to running these cookies on your website.