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Influential psychiatrist Robert Spitzer, who is credited with establishing a modern classification of mental disorders, has died at the age of 83.

Dr. Robert Spitzer played a leading role in the development of the Diagnostic and Statistical Manual of Mental Disorders (DSM).

The American psychiatrist was also lauded for pushing to remove homosexuality’s classification as a mental disorder in 1973.

Dr. Robert Spitzer’s wife said he died from heart problems in Seattle on December 25.Robert Spitzer dead at 83

His work on several editions of the field’s diagnostic manual, known as the DSM, was seen as a “major breakthrough in the profession”, his wife and colleague Janet Williams told the AP.

The DSM helped to give psychiatrists definitions of all of the major disorders so that they “could agree on what they were seeing”, she said.

Working from Columbia University in New York, Robert Spitzer pioneered an approach that relied on empirical study rather than traditional theory.

Robert Spitzer was “by far the most influential psychiatrist of his time,” Dr. Allen Frances, editor of a later edition of the DSM manual, told the New York Times.

Homosexuality, which at the time was listed as a mental disorder, was among the behaviors Dr. Robert Spitzer analyzed and later removed from the list in the 1970s.

Until that point, the DSM had classified homosexuality as an illness, designating it a “sociopathic personality disturbance.”

Dr. Robert Spitzer said he pressed for the change after meeting gay rights activists and determining that homosexuality could not be a disorder if gay people were comfortable with their s** life.

“A medical disorder either had to be associated with subjective distress, pain or general impairment in social function,” he told the Washington Post.

Dr. Jack Drescher, a gay psychoanalyst, described it as a major advance for gay rights.

“The fact that gay marriage is allowed today is in part owed to Bob Spitzer,” he told the New York Times.

However, Bob Spitzer later courted controversy after publishing a study in 2001 which purported to support reparative therapy to turn gay people straight, sparking claims of betrayal from gay rights activists.

More than 10 years later, he apologized for the study, which he said was flawed.

Bob Spitzer said it was the only thing in his career that he regretted.I


Experts say antipsychotic drugs are seen as the most effective treatment of psychotic episodes, but they are also recognized to have devastating side effects.

Doctors say many patients don’t like taking medication long term, but a study published in the Lancet suggests that taking antipsychotic medication more than halves the risk of relapse in schizophrenic patients.

David Strange was diagnosed with paranoid schizophrenia when he was 25. He was sectioned and given antipsychotic drugs, which he says made him feel “a bit better for a while,” but gave him a succession of unpleasant side effects.

But without medication, the voice he hears is a constant stream of abuse that “comments on what other people are thinking and the horrible things they want to do to me”.

“I used to see nasty, dirty rat-like things running around when I went outside, I could see people in the streets screaming abuse at me and making obscene and threatening gestures.

“I was hearing a voice that was saying all kinds of nasty things about me. I was terrified, I tried to kill myself.”

Professor of psychiatry Stefan Leucht, from the Technische Universitat in Munich, led the latest research. He also found that fewer patients on antipsychotic drugs were readmitted to hospital – one of the highest costs associated with mental illnesses.

David Strange says taking antipsychotic drugs for 14 years has helped him deal with his hallucinations and the voices he hears. They are still present but they no longer dominate his life.

One of the many drugs David Strange was given was thioridazine, which gave him an irregular heartbeat, something which can be potentially fatal. He remembers lying down with his heart beating really fast, thinking he did not have long left to live.

“Some drugs made me so anxious I tried to kill myself and ended up getting locked up in hospital.”

Even what he refers to as the “good ones” give him muscle and joint pain, jerkiness similar to the symptoms of Parkinson’s disease and severe sexual dysfunction.

But he says he would still rather take the drugs than try and function without them.

“Being unmedicated is an unliveable hell. I’m happy to put up with all of this just to be more functional and less scared.”

Antipsychotic drugs are seen as the most effective treatment of psychotic episodes, but they are also recognized to have devastating side effects

Antipsychotic drugs are seen as the most effective treatment of psychotic episodes, but they are also recognized to have devastating side effects

The longer antipsychotic drugs are taken, the more chronic the side effects become. The nature of mental illness means patients are often prescribed medication for the rest of their lives.

Daniel Levy, 54, has bipolar disorder and has been taking antipsychotic drugs for nearly 30 years. During that time he has been sectioned and has also attempted suicide.

“The drug chlorpromazine made me tremble, it also made me dribble. When I first became ill I was warned there are certain drugs that weaken the lower lip, even now I still dribble.

“I don’t know I’m doing it until I notice it on my clothes. It looks absolutely terrible.”

But the drug did help him to stay out of hospital and was effective in controlling his symptoms.

“The side effects are the price I pay for keeping out of hospital,” says Daniel Levy.

“It’s a balancing act – doctors never know in advance how you will react to a particular drug.”

Newer “atypical” antipsychotic drugs show fewer of the physical tremor-inducing side effects and are commonly prescribed to patients starting treatment for the first time, says Dr. Oliver Howes from the Institute of Psychiatry, UK.

These still often lead to severe weight gain, increasing the risk of diabetes, blood clots and cardiovascular diseases. The risk is especially high for patients who stay on medication for many decades.

“We have no way of knowing in advance if a given drug is going to suit a patient – so sometimes patients have to try several before they find one that both helps them and is tolerable,” says Dr. Oliver Howes.

Unfortunately the drugs with the most side effects are also the ones which have been shown to be the most effective and are supported by many years of research, says Prof. Stefan Leucht.

He says that if a patient experiences unpleasant side effects, their clinician should always try another drug, but acknowledges that this is not always possible in practice as some doctors are afraid to change their patient’s medication if it appears to be working well.

Dr. Oliver Howes says the side effects of antipsychotics need to be put into perspective.

“Mental health illnesses are devastating. There is a substantial loss of life associated with illnesses such as schizophrenia, predominantly from suicide. We want to prevent that.”

• Antipsychotic medication helps weaken delusions and hallucinations. It can control (but not cure) symptoms in about four out of five people

• Older antipsychotics work by reducing the action of a chemical in the brain called dopamine. They can cause side effects such as stiffness, shakiness, restlessness, sexual problems and unwanted movements, mainly of the mouth and tongue

• Newer antipsychotics work on different chemicals in the brain. These are less likely to produce unwanted movements but can cause weight gain, diabetes, tiredness and sexual problems

Source: Royal College of Psychiatrists