US scientists have recently identified a possible genetic link between diabetes and Alzheimer’s disease.
It has been known for some time that people with diabetes have a much higher risk of developing Alzheimer’s, but not why this is so.
Now researchers writing in Genetics say a study of worms has indicated a known Alzheimer’s gene also plays a role in the way insulin is processed.
Dementia experts said more work in humans was now needed.
US scientists have recently identified a possible genetic link between diabetes and Alzheimer's disease
Alzheimer’s is the most common cause of dementia.
There are medications which can slow the progress of the disease, but none that can halt its progress.
A key indication of Alzheimer’s, which can only be seen after death, is the presence of sticky plaques of amyloid protein in decimated portions of patients’ brains.
Scientists have already found mutations in a gene involved in the processing of amyloid protein in Alzheimer’s which run in families.
In this study, a team from the City College of New York looked at a similar gene in the nematode worms (C. elegans).
These worms are often studied because they, perhaps surprisingly, a useful model for human research.
The researchers, led by Prof. Chris Li, found the gene in the worms also affected the insulin pathway – the chemical reactions involved in its production and processing.
Prof. Chris Li said: “People with type 2 diabetes have an increased risk of dementia.
“The insulin pathways are involved in many metabolic processes, including helping to keep the nervous system healthy.”
She said more work was needed to investigate this potential link and its effects further.
Mark Johnston, editor-in-chief of the journal Genetics, said it was “an important discovery”.
“We know there’s a link between Alzheimer’s and diabetes, but until now it was somewhat of a mystery.
“This finding could open new doors for treating and preventing the disease.”
US researchers have used a blood sample from mother and saliva from father to sequence the genome of a foetus in the womb.
At the time, the mother was just 18 weeks into the pregnancy.
The doctors said the findings, reported in Science Translational Medicine, could eventually lead to foetuses being screened for thousands of genetic disorders in a single and safe test.
However, they also caution it would raise “many ethical questions”.
US researchers have used a blood sample from mother and saliva from father to sequence the genome of a foetus in the womb
The scientists at the University of Washington used pieces of the foetus’ DNA which naturally float around in the pregnant woman’s blood.
These fragments were then pieced together using the parents’ DNA as a guide to build a complete “map” of the foetus’s genome.
They then compared the genetic map drawn 18 weeks into pregnancy with the foetus’ actual DNA taken from the umbilical cord after birth. It was 98% accurate.
The researchers hope their findings will one day be used to test safely for genetic diseases.
Tests do already exist such as those for Down’s syndrome. To test for Down’s syndrome a sample is taken from the sac around the developing foetus, which comes with a risk of miscarriage.
They also say new genetic defects, which are not present in the parents, could be picked up if the technique could be improved. Such mutations form in the eggs, sperm or at conception.
There were 44 new mutations in the foetus and the screen at 18 weeks found 39 of them. However, the screening also detected 25 million possible new mutations or false positives.
One of the researchers, Dr. Jay Shendure, said: “This work opens up the possibility that we will be able to scan the whole genome of the foetus for more than 3,000 single-gene disorders through a single, non-invasive test.”