Several packs of Nurofen Plus were found to contain Seroquel XL, a powerful anti-psychotic drug used to treat schizophrenia, on Thursday.
Friday, after a safety alert was issued, pharmacists have been told to check each package of Nurofen Plus to look for anti-psychotic drugs after sabotaged packs were found in Boots stores across London the day before.
Nurofen Plus packages containing Seroquel XL blisters have been found in Boots stores in Victoria, Beckenham and Bromley.
Several packs of Nurofen Plus were found to contain Seroquel XL in pharmacies accross London
It is speculated that militant activists for animal protection carried out the sabotage operation with the intention of damaging Nurofen Plus’s producer, Reckitt Benckiser.
The pharmaceutical company may have been targeted because it tests some products on animals, although not Nurofen Plus.
Reckitt Benckiser said Friday that it didn’t know where the drugs had been switched.
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Nurofen Plus packages containing Seroquel XL blisters have been found in Boots stores in Victoria, Beckenham and Bromley.
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Boots’ spokeswoman told the Evening Standard:
“We are working closely with the MHRA to aid investigations and we have communicated with our stores and asked our pharmacists to be extra vigilant by checking the Nurofen Plus packet before selling it.”
The “sabotaged” Nurofen Plus packs – containing a total of 500,000 tablets – have been sent to pharmacies across the UK.
It is suspected that blister strips containing the tablets have been changed while in a wholesalers’ warehouse.
On Thursday, 3 tampered Nurofen Plus packs were discovered in south London, and an immediate investigation is under way to identify whether a group or an activist acting alone was behind the action of changing blisters.
Siân Boisseau, director of Virgo Health, the PR company which represents Nurofen, told the Mail:
“There has been a suggestion that the packets were deliberately put in the wrong boxes.
It was not discovered until the packets arrived in store. It was not in the manufacturing process or supply chain. It is not a mix-up and is still being investigated.”
A Virgo Health spokesman added police were not involved so far but could be in the future.
Patients who accidentally take the antipsychotic Seroquel XL may experience sleepiness and are advised not to operate any tools or machinery until they know how the tablets have affected them.
AstraZeneca, producer of Seroquel, said those who had mistakenly taken the drug should contact their GP and bring the blisters back to the pharmacy where they bought it.
Seroquel XL side effects include dizziness, headache and sleepiness, which affect more than one in ten users.
[googlead tip=”lista_mare” aliniat=”stanga”]Nurofen Plus and Seroquel XL are packaged differently – the blisters containing large capsules of Seroquel XL 50mg tablets have gold and black packaging while the Nurofen Plus pills are smaller and have silver and black packaging.
The Medicines and Healthcare Products Regulatory Agency (MHRA) has asked pharmacists to check 32-tablet packs of Nurofen Plus, which is sold only in pharmacies.
There are three batches of Nurofen Plus which were affected by the alert.
They are: batch number 13JJ, expiry date 03/2014, licence number 00327/0082; 57JJ, 05/2014, 00063/0376, and 49JJ, 05/2014, 00063/0376.
Each batch contains 4,000 -7,500 packages, amounting to around 500,000 tablets.
It said that not all packs are affected.
Ian Holloway, from the MHRA’s defective medicines report centre, said:
“People should check to see if they have any affected packets of Nurofen Plus. If you do, return them to the pharmacy where you bought them from.”
Reckitt Benckiser said “serious investigations” were under way to establish how and who switched the blisters, especially as Seroquel XL is manufactured by a different pharmaceutical company.
Reckitt Benckiser added:
“After careful review of the manufacturing system, manufacturing errors by the makers of Nurofen Plus or Seroquel XL are not thought to be part of the cause at this stage.
We are taking this matter very seriously and are working closely with the regulatory authority, the MHRA, and pharmacies. The MHRA are investigating the issue, and have considerable law enforcement powers.
Nurofen Plus is not available for self-selection from the shop floor – and therefore pharmacists are able to check packs and greatly reduce the likelihood of affected packs being sold.”
Dr. Aomesh Bhatt, medical director for Nurofen Plus, said:
“We are taking this matter extremely seriously and we are working closely with the MHRA.
Additionally, we are in the process of working to ensure the Nurofen Plus packs are double-checked by pharmacy staff before they are handed to customers.
We encourage consumers of Nurofen Plus to be vigilant and, while it is very unlikely, should they find they have a suspect pack or if they have any other concerns, we advise them to speak to the pharmacist where they purchased the product.”
Dr. Bhatt added that Nurofen Plus had a “firm policy” of not testing on animals.
Celebrating George Enescu’s 130th birthday anniversary, an important classical music festival in Europe, George Enescu Festival 2011, will take place in Bucharest, Romania, from September 1, until September 25.
Its 20th edition will also include performances held in Cluj-Napoca (central-western Romania), Sibiu (central Romania) and Timisoara (western Romania).
A large number of world’s leading orchestras and conductors will be present at this biennial event along with great names in Romanian music and nation’s emerging composers. The legacy of the great Romanian composer, George Enescu, is the core of the festival since it was founded in 1958.
Along with Enescu’s compositions, works by Shostakovich, Constantin Silvestri, Dinu Lipatti, Glazunov, Mahler, Bruckner, Liszt, Mozart, Dvořák, Prokofiev, Walton, Rachmaninov, Tchaikovsky, Beethoven, Mahler, Wagner, Vivaldi, Chopin, Bach, Schumann, Brahms, Prokofiev will be interpreted.
Prestigious world’s orchestras, conductors and soloists will perform at George Enescu Festival 2011.
Romanian Athenaeum is the main venue of George Enescu Festival 2011
The Residentie Orkest and Christian Badea, the London Symphony Orchestra with Nicola Benedetti, the Mariinsky Orchestra and Valery Gergiev with the Academic Choir of the Romanian National Radio Society, the Staatskapelle Berlin and Daniel Barenboim, Franz Welser-Möst and the Vienna Philharmonic Orchestra, Vasily Petrenko and the Royal Liverpool Philharmonic Orchestra with Midori, Vadim Repin and the Israel Philharmonic Orchestra with Zubin Mehta and Yefim Bronfman, the Orchestra Sinfonica dell’Accademia Nazionale di Santa Cecilia and Antonio Pappano, the Orchestra National de France and Danielle Gatti with Hélène Grimaud, Denis Matsuev and Han-Na Chiang will perform during “Great Orchestras of the World” series.
“We have a very strong programme, which includes many fascinating contemporary works this year. This is a significant feature of what we are doing to develop our audience for new and existing compositions. The exciting thing is that foreign as well as Romanian artists are bringing their perspectives and ideas to new Romanian music. The Festival will also explore symphonic music from countries not usually associated with it, such as Tunisia, India, Japan and Palestine, in our new ‘World Music’ series.” said Mihai Constantinescu, the Festival’s Manager.
George Enescu Festival 2011 will also have another new series “Music of the 21st Century”.
Fourteen concerts from scores for chamber choir and string quartet to compositions for live instruments and electronic sounds will be played. A recital of new pieces from Iancu Dumitrescu’s Hyperion Ensemble (complete with music by Ana-Maria Avram and Dumitrescu himself) and performances of Guillaume Connesson’s Concerto for cello and orchestra and Cornel Ţăranu’s Remembranza (In memoriam George Enescu).
“In addition to its 21st-century strand, the Festival intends to unite young Romanian composers with their international colleagues for a day of workshops.“ said Constantinescu.
The Academy of Saint Martin in the Fields, the Orchestra of the Age of Enlightenment, the Venice Baroque Orchestra, Il Complesso Barocco and the Amsterdam Baroque Orchestra, Boris Berezovsky, Ian Bostridge, the Fine Arts Quartet, Angelika Kirchschlager, Gidon Kremer, Murray Perahia, Yundi and Christian Zacharias will be also present.
The concert performed by Residentie Orkest of Hague in the opening of George Enescu Festival 2011 will be broadcasted on the Internet on September 1.
The George Enescu International Competition for piano and violin and the Award Gala will also be available for live watching on www.tvr.ro/festivalenescu/
The Independent mentioned the George Enescu Festival 2011, along with Verbier Festival, Bayreuth Festival, Festival D’Aix-en-Provence and Festival de Saint-Denis as important cultural events made more popular through the live streaming technology.
George Enescu appeared as conductor with Philadelphia Orchestra, New York Philharmonic and others American orchestras, he also conducted Orchestre Symphonique de Paris. Yehudi Menuhin was among his pupils.
He was a composer, violinist, pianist, conductor and teacher. He was born in 19 August 1881 in Liveni, Romania and died on May 4, 1955 in Paris, France, where he is known as Georges Enesco.
Romanian Rhapsody No. 1 in A Major, Concert Overture on a theme in Romanian folk character in A Major, Oedipe opera are some of his compositions that will be rendered at George Enescu Festival 2011.
[googlead tip=”patrat_mediu” aliniat=”stanga”]A new treatment for leukemia had amazing results, surprising even the researchers who designed it. The new treatment has eradicated the cancer cells present in the first three patients tested bodies.
Early results of a clinical trial showed that genetically engineered T cells eradicate leukemia cells and thrive.
Scientists from the University of Pennsylvania have genetically engineered patients’ T cells — a type of white blood cell — to attack cancer cells in advanced cases of a common type of leukemia.
The first two of three patients studied, who received the innovative treatment, have been cancer-free for more than one year. In the case of the third patient, over 70% of cancer cells were removed, according to the researchers.
"Microscopic image showing two T cells binding to beads, depicted in yellow, that cause the cells to divide. After the beads are removed, the T cells are infused into cancer patients." (Dr. Carl June / Pennsylvania Medicine)
“In just three weeks, tumors were destroyed, the effect being more violent than we ever have imagined,” said Dr. Carl June, one of the researchers involved in the study.
“Each cell can destroyed thousands of cancer cells,” said June, “each patient have been removed tumors from at least 900 grams.”
“A huge accomplishment”
[googlead tip=”vertical_mare” aliniat=”dreapta”] “This is a huge accomplishment — huge,” said Dr. Lee M. Nadler, dean for clinical and translational research at Harvard Medical School, who discovered the molecule on cancer cells that the Pennsylvania team’s engineered T cells target.
Innovative treatment is using patients’ own T cells, which are extracted from body cells and then genetically modified to attack cancer cells and to multiply and then reintroduced into patients’ blood.
Findings of the trial were reported Wednesday in the New England Journal of Medicine and Science Translational Medicine.
According to LA Times report, for building the cancer-attacking cells, the researchers modified a virus to carry instructions for making a molecule that binds with leukemia cells and directs T cells to kill them. Then they drew blood from three patients who suffered from chronic lymphocytic leukemia and infected their T cells with the virus.
When they infused the blood back into the patients, the engineered T cells successfully eradicated cancer cells, multiplied to more than 1,000 times in number and survived for months. They even produced dormant “memory” T cells that might spring back to life if the cancer was to return.
On average, the team calculated, each engineered T cell eradicated at least 1,000 cancer cells.
Side effects included loss of normal B cells, another type of white blood cell, which are also attacked by the modified T cells, and tumor lysis syndrome, a complication caused by the breakdown of cancer cells.
“We knew [the therapy] could be very potent,” said Dr. David Porter, director of the blood and marrow transplantation program at the Hospital of the University of Pennsylvania in Philadelphia and a coauthor of both papers, which were published in the New England Journal of Medicine and Science Translational Medicine.
“But I don’t think we expected it to be this dramatic on this go-around.”
Bone marrow transplants from healthy donors have been effective in fighting some cancers, including chronic lymphocytic leukemia, but the treatment can cause side effects such as infections, liver and lung damage, even death.
“1/5 of bone marrow transplant recipients may die of complications unrelated to their cancer,” Porter said.
Researchers have been working for many years to develop cancer treatments that leverage a patient’s immune system to kill tumors with much greater precision.
Specialists not involved in the trial said the new discovery is very important because it suggested that T cells could be adapted to destroy a range of cancer cells, including ones of the blood, breast or colon
“It is kind of a holy grail,” said Dr. Gary Schiller, a researcher from UCLA’s Jonsson Comprehensive Cancer Center who was not involved in the trial.
“It would be great if this could be applied to acute leukemia, where there is a terrible unmet medical need,” UCLA’s Schiller said.
Dr. David Porter added:
“Previously efforts to replace risky bone marrow transplants with such engineered T cells proved disappointing because the cells were unable to multiply or survive in patients.”
“This time, the T cells were more robust because the team added extra instructions to their virus to help the T cells multiply, survive and attack more aggressively.”
“About 15,000 patients are diagnosed with chronic lymphocytic leukemia every year. Many can live with the disease for years. Bone marrow transplants are the only treatment that eradicates the cancer.”
[googlead tip=”lista_mare” aliniat=”stanga”]Dr. David Porter cautioned that these were preliminary results and the scientists plan to continue the trial, treating more patients and following them over longer periods.
“The researchers also would like to expand the work to other tumor types and diseases,” Porter said.
The hope, scientists said, is that the method would work for cancers that can kill more ruthlessly and rapidly.
[googlead tip=”patrat_mediu” aliniat=”stanga”]As a result of Monday evening London riots, which shortly spread to the other cities, Metropolitan Police took drastic actions.
Groups of people began attacking officers, wrecking cars with wooden poles and metal bars, and looting shops, this was the London image yesterday in the evening. Violence then spread separately in other parts of the city.
Monday’s violence started in Hackney, Northern London, around 4:20 p.m., local time, after a man was stopped and searched by police, who found nothing.
As a result of the yesterday events, Metropolitan London Police took rapidly drastic actions.
About 16,000 police officers will be placed on London's streets in order to prevent a fourth night of disturbances
[googlead tip=”patrat_mediu” aliniat=”stanga”]About 16,000 police officers will be placed on London’s streets in order to prevent a fourth night of disturbances.
The Metropolitan Police has cancelled leave and drafted in support from 30 forces.
In most of the areas, stores and businesses closed earlier in a bid to avoid the kind of violence and looting that spread yesterday through London.
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PM David Cameron promised to restore the order, recalling British Parliament on next Thursday in response to the “sickening scenes”, which prompted disturbances into the other cities.
Tuesday afternoon, David Cameron met officers in the Metropolitan Police’s Gold command in Lambeth before speaking to emergency service personnel in Croydon.
The PM condemned the “sickening scenes of people looting, vandalizing, thieving, robbing”.
David Cameron sent a message to the rioters:
“You will feel the full force of the law. And if you are old enough to commit these crimes, you are old enough to face the punishment.”
The Parliament recalling will allow Members of the Parliament to “stand together in condemnation of these crimes and to stand together in determination to rebuild these communities”, PM said.
[googlead tip=”lista_medie” aliniat=”stanga”]The Prime Minister has shortened his vacation in Tuscany (Toscana, Italy) to discuss the unrest, which first flared on Saturday after a peaceful march in Tottenham over the deadly shooting of Mark Duggan by police.
PM David Cameron and his wife, Samantha, outside a caffe near Siena, Italy, where they have been in vacation during the last weekend London riots
According to BBC, the Metropolitan force has released what it says will be the “first of many” CCTV images (closed circuit television network) of rioting suspects. In the meantime, 32 persons have appeared in court charged with offences such as burglary and criminal damage during the previous riots.
Among those people were a graphic designer, college students, a youth worker, a university graduate and a man signed up to join the army. Some gave non-London addresses. 18 people were remanded in custody.
Until now, 563 people have been arrested and 105 charged in connection with violence in London.
Stephen Kavanagh, Deputy Assistant Commissioner said the use of plastic bullets, which never before used to deal with riots in England, would be “considered carefully” in case of future disturbances.
He also added: “That does not mean we are scared of using any tactic.”
Officers believe some rioters used BlackBerry Messenger to organize violence.
In this matter, two 18-year-olds were arrested in Folkestone, Kent, and a 16-year-old was being questioned in Glasgow on suspicion of inciting violence through internet social networking sites.
According to the BBC News, the developments related to Monday’s disturbances included:
Violence and looting reported across London, including in Hackney, Croydon, Clapham Junction, Peckham, Lewisham, Stratford and Ealing
3 people being questioned on suspicion of attempted murder after a police officer was injured by a car in Wembley, north-west London, while trying to stop suspected looters
Buildings set alight in several areas, including Croydon where part of the Tramlink service was suspended
In Birmingham, 138 people were arrested after scores of youths smashed windows and looted shops in the shopping area
West Midlands Police said a police station in Holyhead Road in Handsworth, Birmingham, was set alight
Up to 200 youths with masks roamed through Toxteth in Liverpool, while Bristol police said they dealt with outbreaks of disorder involving about 150 people
A Nottinghamshire police station was attacked in the St Ann’s area and 200 tyres were set alight in the street
Police dealt with “small pockets of disorder” in the Chapeltown area of Leeds
The Association of British Insurers said the damages will most probably cost insurers “tens of millions of pounds“.
Highbury Corner Magistrates Court has dealt with a large number of cases arising from the riots in north London.
Those who appeared this afternoon were all male and generally in their 20s, although there were some youths.
Charges were most commonly burglary and criminal damage. There were a large number of guilty pleas entered.
The magistrates said that their powers of punishment were insufficient in the light of the fact that the offences were committed during a riot, which amounted to a “substantial aggravating feature”.
A significant number of those charged were said in court to be of previously good character and had simply been drawn in to the offending.
In one defendant’s case, a lawyer described his client as offending in “a moment of madness”.
However, the force has drafted in special constables and community support officers to ensure five times the usual number of officers for a Tuesday will be on duty. Similar staffing levels will be maintained over three days.
Meanwhile, Scotland Yard said a 26-year-old man found shot in a car in Croydon, amid rioting in the south London town, had died in hospital.
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Tuesday evening has brought the news of a disturbance in Salford, Greater Manchester, where 70 to 80 young people are in a standoff with police, and West Bromwich where youths smashed stores windows.
[googlead tip=”vertical_mare” aliniat=”dreapta”] The books industry has been upended by the expansion of the e-books, and publishers are shifting in opposition to tradition by publishing paperbacks books edition earlier than regular, occasionally less than 6 months after the book came out in hardcover.
It used to be a strict schedule in the books business: first the hardcover edition was printed, and about 12 months after that, the paperback book was published.
E-books have made cost a challenge for publishers and they are considering the right time of a paperback book. There is often a big distance between the price of a fresh hardcover book and its e-book edition. The paperback book and e-book tend to be within a couple of dollars, rendering numerous publishers to speculate if cost-conscious buyers are reading e-books right away instead of waiting for the paperbacks books.
Hardcover book has been the publishing style of the first option for a long time. Authors want to make an impression with their books release, so hardcover is the initial selection when publishing. If a person favors a paperback, he or she will get the book after a long delay.
Books
A hardcover is likely to age far more softly. Paperbacks split, wrinkle and discolor much more quickly. Some people love to have a nice-looking bookshelf. Hardback book is more likely to appear great and even as apposed to a wrinkly paperback book. Although the story contained in a book may be identical, some people will refuse to buy a book if it is not bound in their favored form.
Paperbacks books are generally less expensives than hardcovers. When the editor and author save money in the creation process, the discounts are transferred to the buyer. Being able to effortlessly take a book with you is a great ease. Paperbacks are free of the extra weight and also free of the thickness of a hardcovers books.
Since the large, synchronised release of hardcover and electronic editions of a book currently gather the bulk of the attention the book is likely to get, letting the paperback book edition considerably in the back, publishers state they have a fresh sense of urgency with the paperback.
[googlead tip=”patrat_mare”] Last week involved the trade paperback release of “Swamplandia!”, a debut novel by Karen Russell, 5 months just after it was first printed in hardcover in February.
Anne Messitte, a publisher of Vintage/Anchor, said that when Vintage editors published the paperback of “Swamplandia!”, they chose July to capitalize on product sales to summertime travellers, who tend to favor fiction. “It felt to us like a perfect summer paperback,” she stated about the book, that stories the imaginary ventures of a Florida family members threathened by alligators.
“The Tiger’s Wife,” a fictional book by Téa Obreht, that became available in hardcover in March, will be followed by the paperback book in October, 7 months later.
“Those Guys Have All the Fun: Inside the World of ESPN” by James Andrew Miller and Tom Shales, has hardly been in book shops two months, having showed up on May, and the paperback book edition is already planned for December. Therefore, nonfiction release has been sped up as well.
The entire publishing daily life routine has sped up in recent years. Hardcovers books have less time in book shops, due to the fact the merchants tend to shift them off the shelves more quickly than they used to.
“E-book sales are usually strong in the initial period after the publication date but do not spike again after the paperback comes out”, said Terry Adams, the digital and paperback publisher for Little, Brown & Company. [googlead tip=”lista_mare” aliniat=”dreapta”] Terry Adams released the paperback of “Room,” a book by Emma Donoghue, 8 months after the hardcover book due to the fact hardcover product sales had slowed down but not ceased totally. “The momentum was there, and we wanted to capture the momentum for the paperback,” he said. “For books that rise to a certain level of visibility, you really want to ride the wave.”
However, there are still exceptions to the paperbacks books timetable. A number of publishers said that the 12 months delay was still being the principle for most books. If a book is selling quickly in hardcover, publishers tend to postpone on releasing a paperback book edition. Stieg Larsson’s 3rd book in the Millennium series, “The Girl Who Kicked the Hornet’s Nest,” has not yet been printed in paperback edition in the United States, more than 12 months following the hardcover book was released.
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