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degenerative eye disease

Allen Zderad from Minnesota is now able to see his wife again after ten years of being blind due to a bionic eye.

The 68-year-old man started having serious vision problems around 20 years ago due to a condition known as retinitis pigmentosa, a degenerative eye disease which affects the retina.

Allen Zderad, who worked as a chemist when, was declared effectively blind a decade ago.

The man continued his hobby of woodwork by developing his sense of touch and spatial relationships.Allen Zderad bionic eye

Mayo Clinic researcher and ophthalmologist Dr. Raymond Iezzi Jr. had been working on the Second Sight Argus II retinal prosthesis system when he reached out to Allen Zderad.

Dr. Raymond Iezzi Jr. considered Allen Zderad a suitable candidate for a bionic implant.

During the process, the ophthalmologist fitted 60 electrodes into Allen Zderad’s eye.

The electrodes work by interacting with a special camera attached to the patient’s glasses and a separate computer pack capable of sending information to the electrodes embedded in Allen Zderad’s retina, which then sends signals straight to the optic nerve.

After implant, Allen Zderad, a grandfather of ten, explains that he can’t make out detail, but he can now make out shapes and outlines.

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British researchers have reported that totally blind mice have had their sight restored by injections of light-sensing cells into the eye.

The team in Oxford said their studies closely resemble the treatments that would be needed in people with degenerative eye disease.

Similar results have already been achieved with night-blind mice.

Experts said the field was advancing rapidly, but there were still questions about the quality of vision restored.

Patients with retinitis pigmentosa gradually lose light-sensing cells from the retina and can become blind.

The research team, at the University of Oxford, used mice with a complete lack of light-sensing photoreceptor cells in their retinas. The mice were unable to tell the difference between light and dark.

They injected “precursor” cells which will develop into the building blocks of a retina once inside the eye. Two weeks after the injections a retina had formed, according to the findings presented in the Proceedings of the National Academy of Sciences journal.

British researchers have reported that totally blind mice have had their sight restored by injections of light-sensing cells into the eye

British researchers have reported that totally blind mice have had their sight restored by injections of light-sensing cells into the eye

Prof. Robert MacLaren said: “We have recreated the whole structure, basically it’s the first proof that you can take a completely blind mouse, put the cells in and reconstruct the entire light-sensitive layer.”

Previous studies have achieved similar results with mice that had a partially degenerated retina. Prof. Robert MacLaren said this was like “restoring a whole computer screen rather than repairing individual pixels”.

The mice were tested to see if they fled being in a bright area, if their pupils constricted in response to light and had their brain scanned to see if visual information was being processed by the mind.

Prof Pete Coffee, from the Institute of Ophthalmology at University College London, said the findings were important as they looked at the “most clinically relevant and severe case” of blindness.

“This is probably what you would need to do to restore sight in a patient that has lost their vision,” he said.

However, he said this and similar studies needed to show how good the recovered vision was as brain scans and tests of light sensitivity were not enough.

He said: “Can they tell the difference between a nasty animal and something to eat?”

Prof. Robin Ali published research in the journal Nature showing that transplanting cells could restore vision in night-blind mice and then showed the same technique worked in a range of mice with degenerated retinas.

He said: “These papers demonstrate that it is possible to transplant photoreceptor cells into a range of mice even with a severe level of degeneration.

“I think it’s great that another group is showing the utility of photoreceptor transplantation.”

Researchers are already trialing human embryonic stem cells, at Moorfields Eye Hospital, in patients with Stargardt’s disease. Early results suggest the technique is safe but reliable results will take several years.

Retinal chips or bionic eyes are also being trailed in patients with retinitis pigmentosa.