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Derya Sert, a woman who had the world’s first successful womb transplant, is set to undergo IVF in a bid to fulfill her dream of motherhood.

Speaking in London last week, her surgeon Professor Omer Ozkan revealed that the married housewife has responded so well to treatment that his medical team is confident the first “donor womb” pregnancy is now possible.

But some British experts, including Lord Winston, claim that a pregnancy could cause potentially fatal complications. And the baby would have to be born by caesarean, which carries the risks of surgery.

Prof. Omer Ozkan, who performed the pioneering transplant on 22-year-old Derya Sert in August last year, announced her IVF treatment at a conference attended by the world’s top transplant specialists. The event was organized by Richard Smith, a consultant at Imperial College London who could be ready to perform similar operations on British women in just two years.

Prof. Omer Ozkan, from Akdeniz University in Antalya, Turkey, also revealed three more women are to undergo transplants at his clinic, providing Derya Sert has a healthy baby.

He said: “This is the longest time any woman has gone without rejecting an implanted womb and we wanted to reach the year-and-a-half mark before going ahead. That will hopefully happen in three months’ time as things are looking good so far.”

Prof. Omer Ozkan described Derya Sert’s health as “absolutely normal”, adding: “It’s not only important for us to have this contact for the patient, it’s also important for future cases.”

Derya Sert, who is married to 35-year-old Mustafa, has said: “If I had a magic wand, I would want to be pregnant now. I just want to hold my baby in my arms, to be a mother.”

Derya Sert, who had the world’s first successful womb transplant, is set to undergo IVF in a bid to fulfill her dream of motherhood

Derya Sert, who had the world’s first successful womb transplant, is set to undergo IVF in a bid to fulfill her dream of motherhood

Prof. Omer Ozkan and his team will take two out of eight embryos frozen before Derya Sert’s treatment, thaw them and transfer them into her uterus. The hope is this will lead to at least one baby – or even twins.
Women who have lost their wombs to cancer need to have been free of the disease for at least five years before they can be considered for a transplant.

But womb transplants have been criticized by experts because they are not carried out to “save a life”.

Risks include rejection of the new womb and potential side effects during pregnancy from the powerful anti-rejection drugs.

After the first womb transplant, carried out in Saudi Arabia in 2000, the donated organ “failed” after three months because the blood vessels used to connect it were too narrow and became blocked by clots.

However, Prof. Omer Ozkan does not doubt womb transplants are worth the risks for thousands of women otherwise unable to have a “normal” pregnancy.

He said: “Many people think that womb transplants aren’t necessary because they’re not lifesaving operations and that women have the option of adoption or surrogacy.

“But we’ve had applications from women all over the world wanting womb transplants. This is absolutely necessary for these women: you just have to ask them to realize this.”

A total of 100 women have now been screened by Prof. Omer Ozkan in addition to Derya Sert, who received her healthy organ from a car-crash victim. Ten of these have been selected as possible recipients. Of these, three have been approved for a transplant and have undergone fertility treatment. This has resulted in viable embryos, which have been put on ice.

Prof. Omer Ozkan could now have a race on his hands to become the first doctor to achieve a successful pregnancy from a womb transplant.

Swedish experts carried out two procedures in September, both involving the world’s first mother-to-daughter uterus transplants.

This week, they announced another two operations – a mother-to-daughter and an aunt-to-niece – with more transplants scheduled for early 2013. All involve live transplants, whereas Prof. Omer Ozkan’s Turkish team used wombs from dead donors.

The scientists and doctors at the University of Gothenburg have received approval to complete ten procedures in total. The remaining six procedures, scheduled for next year, include a woman donating to her son’s wife and another giving her womb to her younger sister.

The next step is to begin embryo implantation at the end of 2013.

Doctors are divided over whether to use living or dead donors. Some experts are uncomfortable with taking the womb from a living woman when it is not for life-saving reasons. With live transplants, there are risks to two living patients. However, an organ from a living donor can be a better match.

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Turkish doctors have carried out the world’s first successful womb transplant in a breakthrough that could allow thousands of young women to fulfill their dream of motherhood.

Derya Sert, a young Turkish woman who was born without a womb, received a healthy organ in a seven-hour operation.

Scans show her new womb, which came from a woman who had died in a car crash, to be healthy and working well.

Derya Sert, 22, is due to start IVF treatment in Turkey in September in the hope of conceiving a longed-for child.

She said: “People ask me now if I want a boy or a girl, but it doesn’t make any difference to me, I just want a child a healthy baby.

“If I had a magic wand, I would want to be pregnant now. I just want to hold my baby in my arms, to be a mother.”

Her surgeon, who believes womb transplants will become common in the future, said that some women’s desire to be pregnant is so overwhelming that they would take any risk – even death – to have a child.

Risks range from rejection of the new womb, to potentially fatal complications of pregnancy. Any baby will have to be delivered by caesarean section and the drugs needed to prevent the womb being rejected can raise the risk of cancer and trigger illnesses such as diabetes.

Derya Sert, the first woman in the world who received a womb from a cadaver in a seven-hour operation

Derya Sert, the first woman in the world who received a womb from a cadaver in a seven-hour operation

Womb transplants have been carried out successfully in animals including mice, rats and sheep, who then went on to have offspring.

The operation has been done on a woman once before, in Saudi Arabia in 2000.

But the donated womb, taken from a living donor, withered after three months because the blood vessels used to connect it were too narrow and became blocked by clots.

In August last year, Derya Sert became the first woman in the world to receive a womb from a dead donor.

Using a dead donor allowed her doctors at Akdeniz University Hospital in the Turkish city of Antalya to remove the extra tissue and large blood vessels needed to give the womb a reliable blood supply.

Like one in every 5,000 women, Derya Sert, a housewife married to a car mechanic, was born without a womb. She had never had periods, but her ovaries were healthy and she could produce eggs.

Raised in Anamur, a traditional, conservative town in the country’s southern tip, the farmer’s daughter found it difficult to come to terms with the fact that she would never become pregnant and appealed to doctors for help.

The operation involved leading plastic surgeon Omer Ozkan, seven other doctors and another seven medical staff.

Derya Sert spent six months in hospital and was given powerful immunosuppressant drugs to stop her body rejecting the new womb.

Her periods started three weeks after the operation, a signal that the new womb is working well. Scans show its lining to be healthy. The true test of success will come in September, when up to two of the eight embryos created from Derya Sert’s eggs and her husband’s sperm, and frozen ahead of the transplant, will be inserted into her womb.

Derya Sert said: “We could be so happy if I could be a hope for other women. I wish for them to have the baby they long for.”

Her husband Mustafa, 35, said: “If the baby is a boy, we will name him after our doctor.”

Dr. Omer Ozkan, who has just carried out a full face transplant, has been contacted by women from all over the world desperate to have womb transplants.

But he does not plan to do another of the operations until he has seen if Derya Sert is able to have a healthy baby.

Dr. Omer Ozkan said: “This is the first successful womb transplant but the most difficult stage still lies ahead – learning if the patient can become pregnant and have a baby.”

In Sweden, surgeons at the University of Gothenburg have been given the go-ahead to carry out living transplants in which a mother gives her womb to her daughter.

In UK, Richard Smith, a consultant gynaecological surgeon at Imperial College London, could be ready to operate on British women, using wombs from dead donors, in two to three years. More than 50 potential patients have already come forward.

 

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