Amanda Knox says she will not travel to Italy for the appeals trial over the 2007 murder of British student Meredith Kercher.
“I was already imprisoned as innocent person in Italy,” Amanda Knox said told NBC.
“I just can’t relive that.”
Amanda Knox and her Italian ex-boyfriend Raffaele Sollecito were found guilty in 2009, but acquitted on appeal in 2011.
In March, Italy’s highest court overturned both acquittals, ordering a fresh appeals process.
Amanda Knox spent four years in prison before her acquittal.
Amanda Knox says she will not travel to Italy for the appeals trial over the 2007 murder of British student Meredith Kercher
She said she expected to win another acquittal, but that “common sense” told her not to return to Italy.
“I thought about what it would be like to live my entire life in prison and to lose everything, to lose what I’ve been able to come back to and rebuild,” she said.
“I think about it all the time. It’s so scary. Everything is at stake.”
Amanda Knox is not required to be present in Italy for the new appeal, due to start in Florence on September 30.
However, if her previous conviction is confirmed, Italy would be expected to request her extradition.
Meredith Kercher, from Coulsdon, south London, was found dead in a flat she shared in Perugia with Amanda Knox, a fellow exchange student.
Both Amanda Knox and Raffaele Sollecito maintain their innocence.
Amanda Knox insists that on the night of Meredith Kercher’s death she was at Raffaele Sollecito’s flat, smoking marijuana and watching a film.
Another man – Rudy Guede from Ivory Coast – was convicted in a separate trial and sentenced to 16 years for the killing.
Amanda Knox and her former boyfriend Raffaele Sollecito face a retrial over the 2007 killing of Briton student Meredith Kercher, Italy’s highest court has ordered.
Amanda Knox and Raffaele Sollecito spent four years in jail in Italy for murder but were freed on appeal in October 2011, largely on the grounds DNA evidence was flawed.
Prosecutors appealed and the Court of Cassation overturned the acquittals.
Ivory Coast national Rudy Guede was convicted in a separate trial and sentenced to 16 years.
He was found guilty of sexually assaulting and stabbing Meredith Kercher. Rudy Guede admitted being at the house on the night of the killing in November 2007, but denies murder.
Amanda Knox and her former boyfriend Raffaele Sollecito face a retrial over the 2007 killing of Briton student Meredith Kercher, Italy’s highest court has ordered
Meredith Kercher, from Coulsdon, south London, had been on a year abroad from Leeds University when she was found semi-naked in her bedroom and with her throat cut in the cottage she shared with Amanda Knox.
Prosecutors believed Meredith Kercher was killed in a brutal sex game that went wrong.
Addressing the court on Monday, they urged the judges to “make sure the final curtain does not drop on this shocking and dire crime”.
Amanda Knox’s Italian lawyer, Luciano Ghirga, said on Monday her client was “very anxious” about the latest hearing.
Amanda Knox lives in Seattle and a retrial is likely to take place in absentia, as the US is unlikely to extradite her, analysts say.
Amanda Knox and Raffaele Sollecito were originally sentenced to 26 and 25 years in prison for killing and sexually assaulting Meredith Kercher.