The 26-year-old was open about his substance abuse.
“The music artist known as Mac Miller died today in his Studio City home,” the LA County Department of Medical Examiner-Coroner said in a statement.
“In the late morning of September 7, Malcolm McCormick was found unresponsive…. authorities were called and Miller was pronounced dead at the scene at 11:51.
“At this time, an autopsy is pending and a cause of death has not been determined.”
Mac Miller, whose real name was Malcolm James McCormick, rose to fame after topping US charts with his debut album in 2011.
The rapper released his latest record, Swimming, earlier this year and was due to go on tour.
He went through a well-publicized break-up with singer and girlfriend Ariana Grande earlier this year.
Ariana Grande and Mac Miller, who met in 2012, collaborated on a number of songs and performed together at the One Love Manchester concert in 2017.
Charges were filed against the rapper last month after he was arrested in May for DUI and hit and run.
Ariana Grande spoke out publicly about ending their “toxic relationship” after fans blamed her for his arrest.
She said in a typed message posted on social media:“I am not a babysitter or a mother and no woman should feel that they need to be.”
Ariana Grande said she had “tried to support his sobriety” for years, and was praying that he “figures it all out”.
Born in Pittsburgh, Pennsylvania, Mac Miller began to focus on his music while still at school and released his first mixtape under the name EZ Mac at just 15.
Maturing in the public eye, he starred in a MTV reality series in 2013 which followed him and a group of friends after he moved to Los Angeles to pursue his career.
Mac Miller released a series of albums and EPs across the last decade, collaborating with high-profile artists like Kendrick Lamar and Pharrell Williams.
In his final tweets posted on September 6, the rapper promoted the North American tour he was set to embark on next month.
In a statement confirming his death, Mac Miller’s family said that he was “a bright light in this world for his family, friends and fans”.
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