According to local media, about 40 homes were destroyed in Xinmo village in Maoxian county, after the side of a mountain collapsed at about 06:00 local time.
Rescue teams are frantically searching for survivors trapped beneath rocks.
Pictures posted by the People’s Daily newspaper show bulldozers moving earth and large boulders as the rescue effort continues.
The landslide blocked a 1.2-mile stretch of a river, Xinhua news agency reports, citing local officials.
Local police told state broadcaster CCTV the landslide had been triggered by recent heavy rains in the region and that the situation was made worse by a lack of vegetation in the area.
Roads in the county were closed on June 24 to all traffic except emergency services, the news agency said.
Landslides are a regular danger in mountainous regions of China, especially during heavy rains.
In 2008, 87,000 people were killed when an earthquake struck Wenchuan county in Sichuan province. In Maoxian county, 37 tourists were killed when their coach was buried in a landslide caused by the earthquake.
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