The reasons why were unclear but last November the rapper ended a tour early.
Kanye West had accused fellow rapper Jay-Z of trying to kill him and walked off stage after announcing he would vote for Donald Trump.
Meanwhile, Kim Kardashian, remains on Twitter and has 51 million followers.
She has been promoting her and her husband’s children’s clothing line.
Shortly after Kanye West’s accounts were deactivated, Kim Kardashian tweeted that he had hand drawn a logo for the clothing line.
Fans responded by pleading with her to persuade Kanye West to return.
The rapper had already adopted a quieter approach to social media earlier this year and reportedly deleted some of his previous pro-Trump tweets.
Kanye West’s breakdown also came after Kim Kardashian was robbed of jewellery worth an estimated €10 million ($10.5 million) in Paris in October 2016.
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