The world No 1 coped with a gusty wind on Centre Court to win 7-5 6-3 and equal Steffi Graf’s Open era record of major titles.
Angelique Kerber, 28, had beaten Serena Williams in the Australian Open final in January but could not produce another shock.
Serena Williams ends a losing run at Slams stretching back to Wimbledon in 2015.
Fourteen years since she first won Wimbledon, Serena Williams claimed the title for a seventh time after dropping just one set all tournament.
Serena Williams moves alongside German great Steffi Graf in the all-time list of Grand Slam singles champions, and just two behind overall leader Margaret Court, the Australian who won 13 of her 24 major titles before tennis turned professional in 1968.
Angelique Kerber was the outsider but buoyed by her win over Serena Williams in Melbourne, and the swirling wind added another element of uncertainty to the final.
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